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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccnctm1.1Pisc
targeted mutation 1.1, Piotr Sicinski
MGI:5697676
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ccnctm1.1Pisc/Ccnctm1.1Pisc
Tg(Mx1-cre)1Cgn/0 		Not Specified MGI:5697721
cn2
 		Ccnctm1.1Pisc/Ccnctm1.1Pisc
Tg(Lck-LMO1)11Sjk/0
Tg(Mx1-cre)1Cgn/0 		Not Specified MGI:5697722


Genotype
MGI:5697721
cn1
Allelic
Composition		 Ccnctm1.1Pisc/Ccnctm1.1Pisc
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnctm1.1Pisc mutation (0 available); any Ccnc mutation (27 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:217695 )
N
• mutant mice did not spontaneously develop tumours despite elevated ICN1 levels in bone marrow




Genotype
MGI:5697722
cn2
Allelic
Composition		 Ccnctm1.1Pisc/Ccnctm1.1Pisc
Tg(Lck-LMO1)11Sjk/0
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnctm1.1Pisc mutation (0 available); any Ccnc mutation (27 available)
Tg(Lck-LMO1)11Sjk mutation (0 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:217695 )
• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:217695 )
• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors

immune system
increased T cell derived lymphoma incidence ( J:217695 )
• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors

hematopoietic system
increased T cell derived lymphoma incidence ( J:217695 )
• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory