Phenotypes associated with this allele

• Allele Symbol: Kdm2a^{tm1d(KOMP)Mtok}
• Allele Name: targeted mutation 1d, Makio Tokunaga
• Allele ID: MGI:5697958
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm2a^tm1d(KOMP)Mtok/Kdm2a^tm1d(KOMP)Mtok	involves: C57BL/6 * C57BL/6JJcl * C57BL/6N	MGI:5698056

Genotype
MGI:5698056

hm1

• Allelic Composition: Kdm2a^{tm1d(KOMP)Mtok}/Kdm2a^{tm1d(KOMP)Mtok}
• Genetic Background: involves: C57BL/6 * C57BL/6JJcl * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:217589 )

• mice die between E10.5 and E12.5

nervous system

increased neuron apoptosis ( J:217589 )

• at E10.5

impaired neuron differentiation ( J:217589 )

• arrested neural differentiation in the forebrain as determined by Tubb3 expression

abnormal neuron proliferation ( J:217589 )

• decreased mitotic phase cells at E10.5

abnormal embryonic neuroepithelium morphology ( J:217589 )

• at E10.5, mice contain fewer neuroepithelial cells compared with wild-type mice

• however, brain structures are normal

delayed neural tube closure ( J:217589 )

• in some mice

growth/size/body

embryonic growth retardation ( J:217589 )

• beginning at E8.5

• severe at E10.5

• delayed organogenesis

decreased embryo size ( J:217589 )

• at E9.5

cardiovascular system

abnormal heart looping ( J:217589 )

• at E10.5

small heart ( J:217589 )

• at E10.5

cellular

increased neural crest cell apoptosis ( J:217589 )

• in the neocortex at E10.5

increased neuron apoptosis ( J:217589 )

• at E10.5

impaired neuron differentiation ( J:217589 )

• arrested neural differentiation in the forebrain as determined by Tubb3 expression

abnormal neuron proliferation ( J:217589 )

• decreased mitotic phase cells at E10.5

embryo

increased neural crest cell apoptosis ( J:217589 )

• in the neocortex at E10.5

incomplete embryo turning ( J:217589 )

• in some mice

embryonic growth retardation ( J:217589 )

• beginning at E8.5

• severe at E10.5

• delayed organogenesis

decreased embryo size ( J:217589 )

• at E9.5

abnormal embryonic neuroepithelium morphology ( J:217589 )

• at E10.5, mice contain fewer neuroepithelial cells compared with wild-type mice

• however, brain structures are normal

delayed neural tube closure ( J:217589 )

• in some mice