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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tsc22d3tm1.1Hum
targeted mutation 1.1, Edith Hummler
MGI:5698172
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tsc22d3tm1.1Hum/Y
Tg(Ddx4-cre)1Dcas/0 		involves: 129S1/SvImJ * C57BL/6N * FVB MGI:5700201
cn2
 		Tsc22d3tm1.1Hum/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+ 		involves: 129S1/SvImJ * C57BL/6N * SJL/J MGI:5700198


Genotype
MGI:5700201
cn1
Allelic
Composition		 Tsc22d3tm1.1Hum/Y
Tg(Ddx4-cre)1Dcas/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ddx4-cre)1Dcas mutation (2 available)
Tsc22d3tm1.1Hum mutation (0 available); any Tsc22d3 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminiferous tubule epithelium morphology ( J:226675 )
• disorganized seminiferous epithelium

reproductive system
azoospermia ( J:226675 )
• when expression is disrupted specifically in the male germ cells, hemizygous males have the spermatogenesis failure, sterility, small testis and disrupted seminiferous epithelium as hemizygous null males
abnormal seminiferous tubule epithelium morphology ( J:226675 )
• disorganized seminiferous epithelium
male infertility ( J:226675 )
• complete male sterility

cellular
azoospermia ( J:226675 )
• when expression is disrupted specifically in the male germ cells, hemizygous males have the spermatogenesis failure, sterility, small testis and disrupted seminiferous epithelium as hemizygous null males




Genotype
MGI:5700198
cn2
Allelic
Composition		 Tsc22d3tm1.1Hum/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (109 available)
Tsc22d3tm1.1Hum mutation (0 available); any Tsc22d3 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:226675 )
N
• deletion restricted to Sertoli cells leaves males viable and fertile with normal testicular histology, testis size, and sperm production




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory