All Phenotypes Ino80<tm1.1Jland> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ino80^tm1.1Jland
targeted mutation 1.1, Joseph Landry
MGI:5698242

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ino80^tm1.1Jland/Ino80^tm1.1Jland	B6.129(C3)-Ino80^tm1.1Jland/J	MGI:5698245
cn2	2310065F04Rik^tm1.1Boet/2310065F04Rik^tm1.1Boet Ino80^tm1.1Jland/Ino80^tm1.1Jland Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl	MGI:7645256
cn3	Ino80^tm1.1Jland/Ino80^tm1.1Jland Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:7645253
cn4	2310065F04Rik^tm1.1Boet/2310065F04Rik^tm1.1Boet Ino80^tm1.1Jland/Ino80^tm1.1Jland Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:7645255

Allelic Composition	Ino80^tm1.1Jland/Ino80^tm1.1Jland
Genetic Background	B6.129(C3)-Ino80^tm1.1Jland/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80^tm1.1Jland mutation (1 available); any Ino80 mutation (440 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:101977 )

• mice are viable and fertile

Allelic Composition	2310065F04Rik^tm1.1Boet/2310065F04Rik^tm1.1Boet Ino80^tm1.1Jland/Ino80^tm1.1Jland Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2310065F04Rik^tm1.1Boet mutation (0 available); any 2310065F04Rik mutation (0 available)
Ino80^tm1.1Jland mutation (1 available); any Ino80 mutation (440 available)
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:306156 )

N	• adult mice treated with tamoxifen show complete abrogation of the increased number of Pax7+ muscle stem cells (satellite cells) seen in homozygous 2310065F04Rik^tm1.1Boet mice

Allelic Composition	Ino80^tm1.1Jland/Ino80^tm1.1Jland Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80^tm1.1Jland mutation (1 available); any Ino80 mutation (440 available)
Pax7^tm1(cre)Mrc mutation (2 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:306156 )

N	• mice are viable and do not show any apparent developmental abnormalities and have regular numbers of Pax7+ muscle stem cells (satellite cells)

Allelic Composition	2310065F04Rik^tm1.1Boet/2310065F04Rik^tm1.1Boet Ino80^tm1.1Jland/Ino80^tm1.1Jland Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2310065F04Rik^tm1.1Boet mutation (0 available); any 2310065F04Rik mutation (0 available)
Ino80^tm1.1Jland mutation (1 available); any Ino80 mutation (440 available)
Pax7^tm1(cre)Mrc mutation (2 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:306156 )

N	• the increased body weight seen in homozygous 2310065F04Rik^tm1.1Boet mice is normalized

muscle

muscle phenotype ( J:306156 )

• mice show complete abrogation of the increased number of Pax7+ muscle stem cells (satellite cells) and of the increased EdU-labeled quiescent muscle stem cells, the increased tibialis anterior muscle weight, and the muscle hypertrophy and increased myonuclei numbers in fibers that are seen in homozygous 2310065F04Rik^tm1.1Boet mice

• mice do not show the general myofiber hypertrophy that is seen in homozygous 2310065F04Rik^tm1.1Boet mice 4 weeks after cardiotoxin-induced muscle damage

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