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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Socs1tm1.1Ayr
targeted mutation 1.1, Alexander Y Rudensky
MGI:5698257
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Socs1tm1.1Ayr/Socs1tm1.1Ayr involves: C57BL/6 MGI:5707222


Genotype
MGI:5707222
hm1
Allelic
Composition
Socs1tm1.1Ayr/Socs1tm1.1Ayr
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1.1Ayr mutation (1 available); any Socs1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• fewer numbers of IFNG+ and IL17+ CD4+ T effector cells are observed in brain following EAE induction as compared to controls
• however, numbers are higher than in homozygous Mir155tm1.1Rsky mice
• reduced proliferation of splenic CD4+ T cells following restimulation with MOG35-55 peptide
• intermediate phenotype as compared to homozygous Mir155tm1.1Rsky mice
• intermediate phenotype as compared to mild phenotype observed in homozygous Mir155tm1.1Rsky mice and severe phenotype observed in wild type mice

hematopoietic system
• fewer numbers of IFNG+ and IL17+ CD4+ T effector cells are observed in brain following EAE induction as compared to controls
• however, numbers are higher than in homozygous Mir155tm1.1Rsky mice
• reduced proliferation of splenic CD4+ T cells following restimulation with MOG35-55 peptide
• intermediate phenotype as compared to homozygous Mir155tm1.1Rsky mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory