Phenotypes associated with this allele

• Allele Symbol: Socs1^tm1.1Ayr
• Allele Name: targeted mutation 1.1, Alexander Y Rudensky
• Allele ID: MGI:5698257
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Socs1^tm1.1Ayr/Socs1^tm1.1Ayr	involves: C57BL/6	MGI:5707222

Genotype
MGI:5707222

hm1

• Allelic Composition: Socs1^tm1.1Ayr/Socs1^tm1.1Ayr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased effector memory T-helper cell number ( J:226678 )

• fewer numbers of IFNG+ and IL17+ CD4+ T effector cells are observed in brain following EAE induction as compared to controls

• however, numbers are higher than in homozygous Mir155^tm1.1Rsky mice

abnormal T cell physiology ( J:226678 )

• reduced proliferation of splenic CD4+ T cells following restimulation with MOG_35-55 peptide

• intermediate phenotype as compared to homozygous Mir155^tm1.1Rsky mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:226678 )

• intermediate phenotype as compared to mild phenotype observed in homozygous Mir155^tm1.1Rsky mice and severe phenotype observed in wild type mice

hematopoietic system

decreased effector memory T-helper cell number ( J:226678 )

• fewer numbers of IFNG+ and IL17+ CD4+ T effector cells are observed in brain following EAE induction as compared to controls

• however, numbers are higher than in homozygous Mir155^tm1.1Rsky mice

abnormal T cell physiology ( J:226678 )

• intermediate phenotype as compared to homozygous Mir155^tm1.1Rsky mice

• reduced proliferation of splenic CD4+ T cells following restimulation with MOG_35-55 peptide