Analysis Tools
growth/size/body
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• mice are shorter at birth and shorter stature is seen at weaning and persists into adulthood
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• reduction in nose-to-anus body length
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limbs/digits/tail
short femur
(
J:226676
)
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short tibia
(
J:226676
)
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skeleton
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• chondrocyte proliferation in the tibiae is reduced
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short femur
(
J:226676
)
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short tibia
(
J:226676
)
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• 22% reduction of trabecular volumetric bone mineral density
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• reduction in cortical thickness in the metaphyseal regions of distal femur and proximal tibia, with an 18% reduction in cross-sectional cortical thickness
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• ALP-positive osteoblast cell number is reduced whereas TRAP-positive osteoclast number remains unaltered in trabecular bone on neonatal tibias
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• lower trabecular bone in the metaphyseal regions of distal femur and proximal tibia
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• 41% reduction in trabecular bone volume
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• 33% reduction in trabecular number
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• 15% reduction in trabecular thickness
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• skeletogenesis is abnormal, with all appendicular (the upper and lower limbs) and axial (the skull, the vertebral column, and the rib cage) skeletal elements smaller
• bone marrow mesenchymal stromal cells cultured in osteogenic differentiation media show impeded osteogenic differentiation
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• 20% reduction in the length of the proliferative chondrocyte zone of growth plates
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• 15% reduction in the length of the hypertrophic chondrocyte zone of growth plates
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• embryonic limb mesenchymal cells show decreased chondrogenic differentiation in culture
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• lower dynamic bone formation rate
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• compromised endochondrial ossification
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cellular
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• chondrocyte proliferation in the tibiae is reduced
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