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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd160tm1Yxf
targeted mutation 1, Yang-Xin Fu
MGI:5698520
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd160tm1Yxf/Cd160tm1Yxf C57BL/6-Cd160tm1Yxf MGI:5702313
cx2
 		Cd160tm1Yxf/Cd160tm1Yxf
Rag1tm1Mom/Rag1tm1Mom 		B6.Cg-Rag1tm1Mom Cd160tm1Yxf MGI:5702315


Genotype
MGI:5702313
hm1
Allelic
Composition		 Cd160tm1Yxf/Cd160tm1Yxf
Genetic
Background		 C57BL/6-Cd160tm1Yxf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd160tm1Yxf mutation (1 available); any Cd160 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-gamma secretion ( J:222131 )
• reduced interferon gamma production from splenocytes stimulated by Nk1.1 cross-linking

neoplasm
increased tumor growth/size ( J:222131 )
• increased tumor volume following inoculation with NK-dependent B16 tumor cells as compared to inoculated wild-type mice




Genotype
MGI:5702315
cx2
Allelic
Composition		 Cd160tm1Yxf/Cd160tm1Yxf
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 B6.Cg-Rag1tm1Mom Cd160tm1Yxf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd160tm1Yxf mutation (1 available); any Cd160 mutation (17 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-gamma secretion ( J:222131 )
• reduced interferon gamma production from splenocytes stimulated by Nk1.1 cross-linking

neoplasm
increased tumor growth/size ( J:222131 )
• increased tumor volume/weight following inoculation with NK-dependent B16 or RMA-S (no MHC class I surface expression) tumor cells as compared to homozygous Ragtm1Mom control
• tumors generated by inoculation with RMA (normal MHC class I) cells have weights similar to Ragtm1Mom controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory