About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Brinp1tm1Imts
targeted mutation 1, Ichiro Matsuoka
MGI:5698819
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Brinp1tm1Imts/Brinp1tm1Imts B6J.Cg-Brinp1tm1Imts MGI:5699609


Genotype
MGI:5699609
hm1
Allelic
Composition
Brinp1tm1Imts/Brinp1tm1Imts
Genetic
Background
B6J.Cg-Brinp1tm1Imts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brinp1tm1Imts mutation (0 available); any Brinp1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• adult homozygotes have a body weight that is ~85% of that in wild-type controls
• however, adult brain and hippocampus weights remain normal

behavior/neurological
N
• homozygotes show no significant differences in their sensory abilities (hot plate test), neuromuscular strength (forelimb grip strength in Newton), vertical activity and stereotypic behavior relative to wild-type controls
• in a T-maze alteration test, homozygotes show a significantly lower % of correct responses than wild-type controls at the certain blocks of 3 sessions during repetitive sessions with a short delay period (3 s)
• when task difficulty is raised by prolonging the delay period (>30 s), homozygotes show lower performances, suggesting a mild deficit in working memory
• in the elevated plus maze test, homozygotes show a 1.43-fold longer travel distance, enter 1.82-fold more frequently into the open arms, and spend 2.21-fold longer time in the open arms than wild-type controls
• in the open field test, homozygotes spend significantly more time than wild-type controls in the center area of the apparatus during the first 60 min of the test
• in the light/dark transition test, homozygotes travel 1.54- and 1.34-fold longer distances than wild-type controls in the light and dark boxes, respectively, show a 1.62-fold increase in the number of transitions between dark and light boxes, and tend to spend more time in the light box than wild-type controls
• homozygotes show a markedly short latency in the wire hang test and a significantly shorter latency to fall from the rotating drum in a Rotarod test
• however, homozygotes improve their performance during repeating trials of the Rotarod test in a manner similar to that of wild-type controls
• in the home cage, homozygotes show significantly higher locomotor activity during night time than wild-type controls
• in the open field test, homozygotes show >1.5 times higher locomotor/exploratory activity than wild-type controls throughout the 120 min observation period
• in the social interaction test in a new environment, the total duration of contacts and the mean duration per contact are 61% and 50% less than those of wild-type controls, respectively, suggesting poor social interaction
• however, homozygotes showed a normal physical contact pattern in the home cage

nervous system
• analysis of neuronal differentiation of BrdU-incorporated cells suggests that excess newborn neurons in the subgranular zone (SGZ) of the dentate gyrus continue to differentiate to some extent (i.e. to doublecortin-positive immature neurons) until 2 weeks after their birth, but fail to differentiate further or survive thereafter
• homozygotes show a 1.65-fold increase in the number of parvalbumin expressing interneurons in the hippocampal CA1 subregion relative to wild-type controls
• homozygotes show a 1.65-fold increase in the number of parvalbumin expressing interneurons in the hippocampal CA1 subregion relative to wild-type controls
• homozygotes show increased adult neurogenesis in the subgranular zone (SGZ) of the dentate gyrus resulting in a more immature neuronal population in the granule cell layer
• at 7 and 8 weeks of age, the average number of BrdU-positive cells per section in the SGZ is 1.65- and 1.94-fold greater than in wild-type controls, respectively, with a similar increase noted for Ki-67-positive cells
• at 7 weeks of age, staining of doublecortin (a marker for neuroblast and immature neurons) is stronger in the mutant dentate gyrus than that in wild-type controls

homeostasis/metabolism
N
• homozygotes exhibit normal body temperature

cellular
• analysis of neuronal differentiation of BrdU-incorporated cells suggests that excess newborn neurons in the subgranular zone (SGZ) of the dentate gyrus continue to differentiate to some extent (i.e. to doublecortin-positive immature neurons) until 2 weeks after their birth, but fail to differentiate further or survive thereafter

skeleton
N
• homozygotes exhibit a normal skeleton





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory