Phenotypes associated with this allele

• Allele Symbol: Tg(SOD1*H46R)IAra
• Allele Name: transgene insertion I, Toshiyuki Araki
• Allele ID: MGI:5699320
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(SOD1*H46R)IAra/0	involves: C57BL/6 * DBA/2	MGI:5699329

Genotype
MGI:5699329

tg1

• Allelic Composition: Tg(SOD1*H46R)IAra/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:221350 )

• rotarod scores start to decrease at 18 weeks of age

paralysis ( J:221350 )

• mice develop motor paralysis starting from the hindlimbs, spreading to the rest of the body; disease onset is on average 146 and 157 days in males and females, respectively

• duration of disease is on average 31 and 25 days in males and females, respectively

growth/size/body

weight loss ( J:221350 )

• mice begin to lose weight from 16 weeks of age

mortality/aging

premature death ( J:221350 )

• shorter lifespan, with average lifespan of 177 and 182 days in males and females, respectively

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:221350