Analysis Tools
behavior/neurological
|
• mice develop motor paralysis/motor neuron disease with later disease onset and slower progression than in transgenic mice with only the H46R mtuation; disease onset is on average at 407 and 364 days of age in males and females, respectively
• duration of disease is on average 40 and 62 days in males and females, respectively
• however, mice show normal performance on the rotarod up to 42 weeks of age and normal tibialis muscle fibers at 42 weeks of age
|
growth/size/body
| N |
• mice do not exhibit a notable weight loss up to 42 weeks of age
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hematopoietic system
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
|
immune system
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
|
mortality/aging
|
• average lifespan of 451 and 426 days of age in males and females, respectively
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nervous system
| N |
• mice show normal numbers of spinal motor neurons at 40 weeks of age
|
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
|
astrocytosis
(
J:221350
)
|
• a slight increase in activation of astrocytes is seen in the spinal cords of 40 week old mice
|
