Analysis Tools
behavior/neurological
|
• mice develop motor paralysis/motor neuron disease; disease onset is on average 367 and 350 days in males and females, respectively
• duration of disease is on average 38 and 52 days in males and females, respectively
• however, mice show normal performance on the rotarod up to 42 weeks of age
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nervous system
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
• by 66 weeks of age, mice exhibit a similar level of microglia and astrocyte activation in the spinal cord as in 40 week old Tg(SOD1*H46R)LAra mice
|
astrocytosis
(
J:221350
)
|
• slight increase in activation of astrocytes is seen in the spinal cords of 40 week old mice
• by 66 weeks of age, mice exhibit a similar level of microglia and astrocyte activation in the spinal cord as in 40 week old Tg(SOD1*H46R)LAra mice
|
|
• by 66 weeks of age, mice exhibit spinal motor neuron degeneration
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hematopoietic system
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
• by 66 weeks of age, mice exhibit a similar level of microglia and astrocyte activation in the spinal cord as in 40 week old Tg(SOD1*H46R)LAra mice
|
immune system
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
• by 66 weeks of age, mice exhibit a similar level of microglia and astrocyte activation in the spinal cord as in 40 week old Tg(SOD1*H46R)LAra mice
|
mortality/aging
|
• shorter lifespan, with average lifespan of 405 and 403 days in males and females, respectively
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growth/size/body
| N |
• mice do not exhibit a notable weight loss up to 42 weeks of age
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