Phenotypes associated with this allele

• Allele Symbol: Crx^tm1Smgc
• Allele Name: targeted mutation 1, Shiming Chen
• Allele ID: MGI:5699593
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Crx^tm1Smgc/Crx^+	involves: 129X1/SvJ	MGI:5702300

Genotype
MGI:5702300

ht1

• Allelic Composition: Crx^tm1Smgc/Crx⁺
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rod outer segment abnormalities in Crx^tm1.1Smgc/Crx⁺ and Crx^tm1Smgc/Crx⁺ mice

vision/eye

vision/eye phenotype ( J:211011 )

N • outer nuclear layer normal in thickness

N • chromatin in outer nuclear layer condenses normally

short retina rod cell outer segment ( J:211011 )

• short early but become normal by 1 month

abnormal retina cone cell morphology ( J:211011 )

• cone numbers are normal but mislocalized

• opsin levels are normal but distribution pattern disrupted

abnormal electroretinogram waveform feature ( J:211011 )

• modest deficits in light and dark adapted ERG recordings

• light adapted defects are more severe

nervous system

short retina rod cell outer segment ( J:211011 )

• short early but become normal by 1 month

abnormal retina cone cell morphology ( J:211011 )

• cone numbers are normal but mislocalized

• opsin levels are normal but distribution pattern disrupted