All Phenotypes Bmp4<tm1b(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmp4^{tm1b(EUCOMM)Hmgu}
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:5699604

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp4^{tm1b(EUCOMM)Hmgu}/Bmp4^{tm1b(EUCOMM)Hmgu}	C57BL/6N-Bmp4^{tm1b(EUCOMM)Hmgu}/Bay	MGI:6261986
ht2	Bmp4^{tm1b(EUCOMM)Hmgu}/Bmp4⁺	C57BL/6N-Bmp4^{tm1b(EUCOMM)Hmgu}/Bay	MGI:6288354

Allelic Composition	Bmp4^{tm1b(EUCOMM)Hmgu}/Bmp4^{tm1b(EUCOMM)Hmgu}
Genetic Background	C57BL/6N-Bmp4^{tm1b(EUCOMM)Hmgu}/Bay
Cell Lines	HEPD0739_1_F09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Bmp4 mutation (23 available)

Data Sources

IMPC Data for Bmp4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - BCM

embryo

abnormal embryo development ( J:211773 )

IMPC - BCM

abnormal embryo turning ( J:211773 )

IMPC - BCM

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

abnormal neural tube closure ( J:211773 )

IMPC - BCM

abnormal allantois morphology ( J:211773 )

IMPC - BCM

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - BCM

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

nervous system

abnormal neural tube closure ( J:211773 )

IMPC - BCM

abnormal forebrain development ( J:211773 )

IMPC - BCM

abnormal hindbrain development ( J:211773 )

IMPC - BCM

abnormal midbrain development ( J:211773 )

IMPC - BCM

Allelic Composition	Bmp4^{tm1b(EUCOMM)Hmgu}/Bmp4⁺
Genetic Background	C57BL/6N-Bmp4^{tm1b(EUCOMM)Hmgu}/Bay
Cell Lines	HEPD0739_1_F09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Bmp4 mutation (23 available)

Data Sources

IMPC Data for Bmp4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased anxiety-related response ( J:211773 )

IMPC - BCM

increased grip strength ( J:211773 )

IMPC - BCM

hyperactivity ( J:211773 )

IMPC - BCM

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - BCM

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - BCM

abnormal iris morphology ( J:211773 )

IMPC - BCM

abnormal eye anterior chamber depth ( J:211773 )

IMPC - BCM

microphthalmia ( J:211773 )

IMPC - BCM

eyelids fail to open ( J:211773 )

IMPC - BCM

abnormal retina morphology ( J:211773 )

IMPC - BCM

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - BCM

abnormal retina outer nuclear layer morphology ( J:211773 )

IMPC - BCM

decreased total retina thickness ( J:211773 )

IMPC - BCM

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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