Phenotypes associated with this allele

• Allele Symbol: Aasdhppt^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5700041
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aasdhppt^tm1.1(KOMP)Vlcg/Aasdhppt^tm1.1(KOMP)Vlcg	B6N(Cg)-Aasdhppt^tm1.1(KOMP)Vlcg/J	MGI:6261767
ht2	Aasdhppt^tm1.1(KOMP)Vlcg/Aasdhppt^+	B6N(Cg)-Aasdhppt^tm1.1(KOMP)Vlcg/J	MGI:6261766

Genotype
MGI:6261767

hm1

• Allelic Composition: Aasdhppt^{tm1.1(KOMP)Vlcg}/Aasdhppt^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Aasdhppt^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13348A-C10

Data Sources

IMPC Data for Aasdhppt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Aasdhppt^{tm1.1(KOMP)Vlcg}/Aasdhppt^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form typical outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• normal looking blastocysts are present at E3.5 (19% versus expected 25%, n=59); no homozygous embryos or excess resorption sites are observed at E7.5

• in vitro, blastocysts hatch from the zona pellucida and form typical outgrowth colonies after 3 days in culture

Genotype
MGI:6261766

ht2

• Allelic Composition: Aasdhppt^{tm1.1(KOMP)Vlcg}/Aasdhppt⁺
• Genetic Background: B6N(Cg)-Aasdhppt^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13348A-C10

Data Sources

IMPC Data for Aasdhppt

behavior/neurological

decreased grip strength ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

improved glucose tolerance ( J:211773 )

IMPC - JAX

pigmentation

abnormal iris pigmentation ( J:211773 )

IMPC - JAX

vision/eye

abnormal iris pigmentation ( J:211773 )

IMPC - JAX