Phenotypes associated with this allele

• Allele Symbol: Ryr1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5700047
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ryr1^tm1b(EUCOMM)Hmgu/Ryr1^tm1b(EUCOMM)Hmgu	C57BL/6N-Ryr1^tm1b(EUCOMM)Hmgu/H	MGI:6263413
ht2	Ryr1^tm1b(EUCOMM)Hmgu/Ryr1^+	C57BL/6N-Ryr1^tm1b(EUCOMM)Hmgu/H	MGI:5797788

Genotype
MGI:6263413

hm1

• Allelic Composition: Ryr1^{tm1b(EUCOMM)Hmgu}/Ryr1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ryr1^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0727_2_D11

Data Sources

IMPC Data for Ryr1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5797788

ht2

• Allelic Composition: Ryr1^{tm1b(EUCOMM)Hmgu}/Ryr1⁺
• Genetic Background: C57BL/6N-Ryr1^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0727_2_D11

Data Sources

IMPC Data for Ryr1

growth/size/body

increased spleen weight ( J:211773 )

♀

IMPC - HAR

hematopoietic system

increased spleen weight ( J:211773 )

♀

IMPC - HAR

homeostasis/metabolism

increased respiratory quotient ( J:211773 )

♂

IMPC - HAR

immune system

increased spleen weight ( J:211773 )

♀

IMPC - HAR