About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Topaz1tm1Ics
targeted mutation 1, Mouse Clinical Institute
MGI:5700076
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Topaz1tm1Ics/Topaz1tm1Ics involves: C57BL/6J * C57BL/6N MGI:5700078


Genotype
MGI:5700078
hm1
Allelic
Composition		 Topaz1tm1Ics/Topaz1tm1Ics
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Topaz1tm1Ics mutation (0 available); any Topaz1 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:226405 )
N
• female mice exhibit normal fertility
abnormal male germ cell morphology ( J:226405 )
• mice exhibit germ cell aggregates from P28 onward in the seminiferous tubules unlike wild-type mice
azoospermia ( J:226405 )
• neither round spermatids nor spermatozoa in adult testes
arrest of male meiosis ( J:226405 )
• spermatocytes exhibit aberrant progression through prophase I
• chromosome alignment is abnormal
• however, synaptonemal complex formation and meiotic sex chromosome inactivation are normal
abnormal male germ cell apoptosis ( J:226405 )
• at pachytene stage
decreased testis weight ( J:226405 )
• from P28 onwards

cellular
cellular phenotype ( J:226405 )
N
• male mice exhibit no variation in the expression of retrotransposons in testes
abnormal male germ cell morphology ( J:226405 )
• mice exhibit germ cell aggregates from P28 onward in the seminiferous tubules unlike wild-type mice
azoospermia ( J:226405 )
• neither round spermatids nor spermatozoa in adult testes
arrest of male meiosis ( J:226405 )
• spermatocytes exhibit aberrant progression through prophase I
• chromosome alignment is abnormal
• however, synaptonemal complex formation and meiotic sex chromosome inactivation are normal
abnormal male germ cell apoptosis ( J:226405 )
• at pachytene stage

endocrine/exocrine glands
decreased testis weight ( J:226405 )
• from P28 onwards




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory