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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Topaz1tm1Ics
targeted mutation 1, Mouse Clinical Institute
MGI:5700076
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Topaz1tm1Ics/Topaz1tm1Ics involves: C57BL/6J * C57BL/6N MGI:5700078


Genotype
MGI:5700078
hm1
Allelic
Composition		 Topaz1tm1Ics/Topaz1tm1Ics
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Topaz1tm1Ics mutation (0 available); any Topaz1 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:226405 )
N
• female mice exhibit normal fertility
abnormal male germ cell morphology ( J:226405 )
• mice exhibit germ cell aggregates from P28 onward in the seminiferous tubules unlike wild-type mice
azoospermia ( J:226405 )
• neither round spermatids nor spermatozoa in adult testes
arrest of male meiosis ( J:226405 )
• spermatocytes exhibit aberrant progression through prophase I
• chromosome alignment is abnormal
• however, synaptonemal complex formation and meiotic sex chromosome inactivation are normal
abnormal male germ cell apoptosis ( J:226405 )
• at pachytene stage
decreased testis weight ( J:226405 )
• from P28 onwards

cellular
cellular phenotype ( J:226405 )
N
• male mice exhibit no variation in the expression of retrotransposons in testes
abnormal male germ cell morphology ( J:226405 )
• mice exhibit germ cell aggregates from P28 onward in the seminiferous tubules unlike wild-type mice
azoospermia ( J:226405 )
• neither round spermatids nor spermatozoa in adult testes
arrest of male meiosis ( J:226405 )
• spermatocytes exhibit aberrant progression through prophase I
• chromosome alignment is abnormal
• however, synaptonemal complex formation and meiotic sex chromosome inactivation are normal
abnormal male germ cell apoptosis ( J:226405 )
• at pachytene stage

endocrine/exocrine glands
decreased testis weight ( J:226405 )
• from P28 onwards




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory