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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Topaz1tm1Ics
targeted mutation 1, Mouse Clinical Institute
MGI:5700076
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Topaz1tm1Ics/Topaz1tm1Ics involves: C57BL/6J * C57BL/6N MGI:5700078


Genotype
MGI:5700078
hm1
Allelic
Composition
Topaz1tm1Ics/Topaz1tm1Ics
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Topaz1tm1Ics mutation (0 available); any Topaz1 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice exhibit normal fertility
• mice exhibit germ cell aggregates from P28 onward in the seminiferous tubules unlike wild-type mice
• neither round spermatids nor spermatozoa in adult testes
• spermatocytes exhibit aberrant progression through prophase I
• chromosome alignment is abnormal
• however, synaptonemal complex formation and meiotic sex chromosome inactivation are normal
• at pachytene stage
• from P28 onwards

cellular
N
• male mice exhibit no variation in the expression of retrotransposons in testes
• mice exhibit germ cell aggregates from P28 onward in the seminiferous tubules unlike wild-type mice
• neither round spermatids nor spermatozoa in adult testes
• spermatocytes exhibit aberrant progression through prophase I
• chromosome alignment is abnormal
• however, synaptonemal complex formation and meiotic sex chromosome inactivation are normal
• at pachytene stage

endocrine/exocrine glands
• from P28 onwards





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory