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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Plp1-HTT*150Q)4aXjl
transgene insertion 4a, Xiao-Jiang Li
MGI:5700344
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Plp1-HTT*150Q)4aXjl/0 Not Specified MGI:5700345


Genotype
MGI:5700345
tg1
Allelic
Composition
Tg(Plp1-HTT*150Q)4aXjl/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice start to die at 5 months of age and do not survive past 10 months

growth/size/body
• body weight begins to decrease at 4 months of age and continues to decrease progressively

behavior/neurological
• mice show increased sensitivity to flurothyl-induced seizures
• 5 month old mice exhibit difficulty walking
• 5 month old mice exhibit clasping
• 5 month old mice exhibit tremors
• progressive motor dysfunction on the rotarod with age
• locomotor activity is lower during active times (7 pm to 11 pm)

nervous system
• mice show increased sensitivity to flurothyl-induced seizures
• degenerated axons, appearing swollen and dark, are seen at 5 months of age, but not at 3 months
• reduction of myelination in striatum axons is seen at 3 months but not earlier and becomes more severe at 5 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:221608





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory