mortality/aging
• mice start to die at 5 months of age and do not survive past 10 months
|
growth/size/body
weight loss
(
J:221608
)
• body weight begins to decrease at 4 months of age and continues to decrease progressively
|
behavior/neurological
• mice show increased sensitivity to flurothyl-induced seizures
|
• 5 month old mice exhibit difficulty walking
|
• 5 month old mice exhibit clasping
|
• progressive motor dysfunction on the rotarod with age
|
• locomotor activity is lower during active times (7 pm to 11 pm)
|
nervous system
• mice show increased sensitivity to flurothyl-induced seizures
|
• degenerated axons, appearing swollen and dark, are seen at 5 months of age, but not at 3 months
|
• reduction of myelination in striatum axons is seen at 3 months but not earlier and becomes more severe at 5 months of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Huntington's disease | DOID:12858 |
OMIM:143100 |
J:221608 |