Phenotypes associated with this allele

• Allele Symbol: Alk^tm1Swm
• Allele Name: targeted mutation 1, Stephan W Morris
• Allele ID: MGI:5700377
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alk^tm1Swm/Alk^tm1Swm	involves: 129P2/OlaHsd * C57BL/6J	MGI:5708292

Genotype
MGI:5708292

hm1

• Allelic Composition: Alk^tm1Swm/Alk^tm1Swm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:227538 )

N • homozygotes are viable, fertile and exhibit no gross locomotor defects, either under naive conditions or in response to saline

N • water consumption is normal

increased alcohol consumption ( J:227538 )

• in a limited-access binge drinking model, homozygotes show increased overall consumption of a 20% ethanol solution relative to wild-type controls, as measured in g/kg over a 4-hr period 3 times per week during the dark cycle, for a total of 8 sessions

• following the final drinking session, homozygores reach significantly higher blood ethanol concentration (BEC) levels (>0.08%) than wild-type controls (>0.04%)

• however, no significant differences in general fluid (water) intake are observed under the same conditions

enhanced behavioral response to alcohol ( J:227538 )

• in a loss of righting reflex test, adult homozygotes of both sexes show a significant increase in the amount of time to recover the righting reflex at high sedating doses of ethanol (3.6 and 4.0 g/kg), indicating increased sedation in response to ethanol

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:227538 )

N • homozygotes exhibit normal ethanol metabolism and clearance, as determined by BECs at various time points after an injection of 4.0 g/kg ethanol