All Phenotypes Thrb<tm3.1Df> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Thrb^tm3.1Df
targeted mutation 3.1, Douglas Forrest
MGI:5701356

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrb^tm3.1Df/Thrb^tm3.1Df	B6J.Cg-Thrb^tm3.1Df	MGI:5701359

Allelic Composition	Thrb^tm3.1Df/Thrb^tm3.1Df
Genetic Background	B6J.Cg-Thrb^tm3.1Df

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm3.1Df mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:222168 )

• both males and females show little or no expansion of the 20-alpha-hydroxysteroid dehydrogenase-positive zone of the adrenal cortex in response to T3 (triiodothyronine) unlike controls which show expansion of this zone when treated with T3 from P14 to P28, indicating resistance to T3 action

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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