About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir182tm1.1Dgk
targeted mutation 1.1, David Kirsch
MGI:5702430
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir182tm1.1Dgk/Mir182tm1.1Dgk involves: 129/Sv * C57BL/6 MGI:5704431
cn2
 		Krastm4Tyj/Krastm4Tyj
Mir182tm1.1Dgk/Mir182tm1.1Dgk
Trp53tm1Brn/Trp53tm1Brn 		involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5704424
cn3
 		Krastm4Tyj/Krastm4Tyj
Mir182tm1.1Dgk/Mir182+
Trp53tm1Brn/Trp53tm1Brn 		involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5704427


Genotype
MGI:5704431
hm1
Allelic
Composition		 Mir182tm1.1Dgk/Mir182tm1.1Dgk
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir182tm1.1Dgk mutation (1 available); any Mir182 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:217635 )
• mice are viable and fertile




Genotype
MGI:5704424
cn2
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Mir182tm1.1Dgk/Mir182tm1.1Dgk
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (12 available); any Kras mutation (90 available)
Mir182tm1.1Dgk mutation (1 available); any Mir182 mutation (8 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (244 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:217635 )
• 13% of mice develop lung metastases within 6 months following amputation of limb injected with cre-expressing adenovirus
• in the absence of the Mir18tm1.1Dgk allele, 43% of mice develop lung metastases
• number of metastatic nodules and metastatic burden in the lung are decreased compared to mice without the Mir18tm1.1Dgk allele




Genotype
MGI:5704427
cn3
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Mir182tm1.1Dgk/Mir182+
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (12 available); any Kras mutation (90 available)
Mir182tm1.1Dgk mutation (1 available); any Mir182 mutation (8 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (244 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:217635 )
• 20% of mice develop lung metastases by 120 days following amputation of limb injected with cre-expressing adenovirus
• in the absence of the Mir18tm1.1Dgk allele, 43% of mice develop lung metastases
• number of metastatic nodules and metastatic burden in the lung are decreased compared to mice without the Mir18tm1.1Dgk allele




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory