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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-Mir182)Dgk
targeted mutation 1, David Kirsch
MGI:5702434
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gt(ROSA)26Sortm1(CAG-Mir182)Dgk/Gt(ROSA)26Sortm1(CAG-Mir182)Dgk involves: 129/Sv * C57BL/6 MGI:5704432
cn2
 		Gt(ROSA)26Sortm1(CAG-Mir182)Dgk/Gt(ROSA)26Sortm1(CAG-Mir182)Dgk
Krastm4Tyj/Krastm4Tyj
Trp53tm1Brn/Trp53tm1Brn 		involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5704425


Genotype
MGI:5704432
hm1
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Mir182)Dgk/Gt(ROSA)26Sortm1(CAG-Mir182)Dgk
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Mir182)Dgk mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:217635 )
• mice are viable and fertile




Genotype
MGI:5704425
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Mir182)Dgk/Gt(ROSA)26Sortm1(CAG-Mir182)Dgk
Krastm4Tyj/Krastm4Tyj
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Mir182)Dgk mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased metastatic potential ( J:217635 )
• 75% of mice develop lung metastases by 120 days following amputation of limb injected with cre-expressing adenovirus
• in the absence of the Gt(ROSA)26Sortm1(CAG-Mir182)Dgk allele, 43% of mice develop lung metastases
• number of number of metastatic nodules in the lung is increased compared to mice without the Gt(ROSA)26Sortm1(CAG-Mir182)Dgk allel




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory