Analysis Tools
cellular
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• at E18.5 there is incomplete transgene expression in the hair cells of the organ of Corti resulting in a mosaic phenotype in which those hair cells that express the transgene have abnormal hair cell orientation and skewed intrinsic asymmetry, and there is a gradient of severity of defects in kinocilia orientation such that kineocilia in row 1 outer hair cells seem inverted while the alterations in OHC2 and OHC3 are less severe and have the kinocilia positioned at the medial and lateral surface, respectively. In the hair cells expressing the transgene, the bare zone is almost absent, the microvilli/stereocilia and underlying cuticular plate occupy most of the diminished apical surface, and kinocilia are abnormally close to cell junctions
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hearing/vestibular/ear
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• at E18.5 there is incomplete transgene expression in the hair cells of the organ of Corti resulting in a mosaic phenotype in which those hair cells that express the transgene have abnormal hair cell orientation and skewed intrinsic asymmetry, and there is a gradient of severity of defects in kinocilia orientation such that kineocilia in row 1 outer hair cells seem inverted while the alterations in OHC2 and OHC3 are less severe and have the kinocilia positioned at the medial and lateral surface, respectively. In the hair cells expressing the transgene, the bare zone is almost absent, the microvilli/stereocilia and underlying cuticular plate occupy most of the diminished apical surface, and kinocilia are abnormally close to cell junctions
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nervous system
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• at E18.5 there is incomplete transgene expression in the hair cells of the organ of Corti resulting in a mosaic phenotype in which those hair cells that express the transgene have abnormal hair cell orientation and skewed intrinsic asymmetry, and there is a gradient of severity of defects in kinocilia orientation such that kineocilia in row 1 outer hair cells seem inverted while the alterations in OHC2 and OHC3 are less severe and have the kinocilia positioned at the medial and lateral surface, respectively. In the hair cells expressing the transgene, the bare zone is almost absent, the microvilli/stereocilia and underlying cuticular plate occupy most of the diminished apical surface, and kinocilia are abnormally close to cell junctions
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