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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(RasE)290Biat
transgene insertion 290, Biomodels Austria
MGI:5702681
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(RasE)290Biat/0 involves: C57BL/6 * DBA/2 MGI:5770441
cn2
 		Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Tg(RasE)290Biat/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5770438
cn3
 		Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Ptentm2Mak/Ptentm2Mak
Tg(RasE)290Biat/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5770439
tg4
 		Tg(RasE)290Biat/0 involves: C57BL/6 * DBA/2 MGI:5770437


Genotype
MGI:5770441
cn1
Allelic
Composition		 Tg(RasE)290Biat/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RasE)290Biat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenocarcinoma incidence ( J:226601 )
• mice inhaling adenoviral particles expressing cre recombinase (AdCre) develop pan-cytokeratin-positive lung adenocarcinomas; about 85% of tumors show simultaneous activation of the three alleles
• lung tumors expressing all three alleles are slightly bigger than tumors not expressing all three alleles
• substantial percentage of triple allele activated tumors are invasive while non-triple allele activated tumors are noninvasive
• mice inhaling AdCre particles do not develop pancreatic or skin-appendage tumors

respiratory system
increased lung adenocarcinoma incidence ( J:226601 )
• mice inhaling adenoviral particles expressing cre recombinase (AdCre) develop pan-cytokeratin-positive lung adenocarcinomas; about 85% of tumors show simultaneous activation of the three alleles
• lung tumors expressing all three alleles are slightly bigger than tumors not expressing all three alleles
• substantial percentage of triple allele activated tumors are invasive while non-triple allele activated tumors are noninvasive
• mice inhaling AdCre particles do not develop pancreatic or skin-appendage tumors




Genotype
MGI:5770438
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Tg(RasE)290Biat/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(RasE)290Biat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sebaceous gland tumor incidence ( J:226601 )
• about 80% of tamoxifen-injected mice develop tumors in the skin which immunohistochemistry suggests are skin-appendage tumors derived from sebaceous glands
• skin-appendage tumors develop when 4-OH tamoxifen is applied atopically onto the back of the skin; 98.3% of tumors show simultaneous activation of the three alleles
increased pancreas tumor incidence ( J:226601 )
• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection
increased pancreatic ductal adenocarcinoma incidence ( J:226601 )
• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas
increased pancreatic intraepithelial neoplasia incidence ( J:226601 )
• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas
increased lung tumor incidence ( J:226601 )
• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection
increased lung adenocarcinoma incidence ( J:226601 )
• lung tumors of tamoxifen treated mice are adenocarcinomas

endocrine/exocrine glands
increased sebaceous gland tumor incidence ( J:226601 )
• about 80% of tamoxifen-injected mice develop tumors in the skin which immunohistochemistry suggests are skin-appendage tumors derived from sebaceous glands
• skin-appendage tumors develop when 4-OH tamoxifen is applied atopically onto the back of the skin; 98.3% of tumors show simultaneous activation of the three alleles
increased pancreas tumor incidence ( J:226601 )
• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection
increased pancreatic ductal adenocarcinoma incidence ( J:226601 )
• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas
increased pancreatic intraepithelial neoplasia incidence ( J:226601 )
• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

respiratory system
increased lung tumor incidence ( J:226601 )
• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection
increased lung adenocarcinoma incidence ( J:226601 )
• lung tumors of tamoxifen treated mice are adenocarcinomas

integument
increased sebaceous gland tumor incidence ( J:226601 )
• about 80% of tamoxifen-injected mice develop tumors in the skin which immunohistochemistry suggests are skin-appendage tumors derived from sebaceous glands
• skin-appendage tumors develop when 4-OH tamoxifen is applied atopically onto the back of the skin; 98.3% of tumors show simultaneous activation of the three alleles




Genotype
MGI:5770439
cn3
Allelic
Composition		 Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Ptentm2Mak/Ptentm2Mak
Tg(RasE)290Biat/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Ptentm2Mak mutation (4 available); any Pten mutation (88 available)
Tg(RasE)290Biat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:226601 )
• tamoxifen treated mice exhibit shortened lifespan

neoplasm
increased pancreas tumor incidence ( J:226601 )
• tamoxifen treated mice exhibit accelerated formation of lung and pancreatic tumors compared to single Tg(RasE)290Biat transgenics
increased lung tumor incidence ( J:226601 )
• tamoxifen treated mice exhibit accelerated formation of lung and pancreatic tumors compared to single Tg(RasE)290Biat transgenics

endocrine/exocrine glands
increased pancreas tumor incidence ( J:226601 )
• tamoxifen treated mice exhibit accelerated formation of lung and pancreatic tumors compared to single Tg(RasE)290Biat transgenics

respiratory system
increased lung tumor incidence ( J:226601 )
• tamoxifen treated mice exhibit accelerated formation of lung and pancreatic tumors compared to single Tg(RasE)290Biat transgenics




Genotype
MGI:5770437
tg4
Allelic
Composition		 Tg(RasE)290Biat/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RasE)290Biat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:226601 )
N
• mice do not develop tumors up to 2 years of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory