All Phenotypes Tcim<tm1Icle> MGI Mouse

• overall increase in hematopoietic activity

increased common myeloid progenitor cell number ( J:217318 )

• significant increase in colony forming unit granulocyte-erythroid-monocyte-megakaryocyte (CFU-GEMM) in the bone marrow

myeloid hyperplasia ( J:217318 )

• markedly increased myeloid cell number in peripheral blood

increased granulocyte monocyte progenitor cell number ( J:217318 )

• significant increase in colony forming unit granulocyte macrophage (CFU-GM) cell number in the bone marrow

increased erythroid progenitor cell number ( J:217318 )

• significant increase in colony forming unit erythroid (CFU-E) number in the bone marrow

• however, burst-forming unit-erythroid (BFU-E) number is normal

abnormal erythrocyte morphology ( J:217318 )

• increased number of small-sized RBCs, as shown by significantly reduced mean corpuscular volume and mean corpuscular hemoglobin

• however, hematocrit and mean corpuscular hemoglobin concentration remain normal

increased erythrocyte cell number ( J:217318 )

• 6.86% increase in RBC count in peripheral blood

decreased mean corpuscular hemoglobin ( J:217318 )

• significant decrease in mean corpuscular hemoglobin

decreased mean corpuscular volume ( J:217318 )

• significant decrease in mean corpuscular volume

increased red blood cell distribution width ( J:217318 )

• higher RBC distribution width (RDW) in peripheral blood, indicating RBC size variation

increased leukocyte cell number ( J:217318 )

• 56.3% increase in peripheral blood total WBC counts in young adults relative to age- and sex-matched wild type controls

increased eosinophil cell number ( J:217318 )

• marked increase in eosinophil number

increased neutrophil cell number ( J:217318 )

• 2.8-fold increase in neutrophil number

increased hematopoietic stem cell number ( J:217318 )

• significant expansion of Lin^-Sca-1⁺c-Kit⁺ (LSK) cells in the bone marrow

• CD150^-CD48⁺ cells are increased in gated LSK cells, suggesting that lineage-restricted hematopoietic progenitor cells are expanded preferentially

abnormal mononuclear cell morphology ( J:217318 )

• increased expression of Cd11b and F4/80, myeloid and macrophage/ monocyte markers respectively, in peripheral blood mononuclear cells

increased lymphocyte cell number ( J:217318 )

• 44.1% increase in lymphocyte number

• however, the % of lymphocytes in total WBC is reduced by 11.1%, reflecting steeper increase of myeloid cells

increased monocyte cell number ( J:217318 )

• marked increase in monocyte number