behavior/neurological
• females exhibit milder motor coordination and behavioral phenotypes than males
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Allele Symbol Allele Name Allele ID |
Mecp2tm6.1Bird targeted mutation 6.1, Adrian Bird MGI:5702868 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• females exhibit milder motor coordination and behavioral phenotypes than males
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• motor coordination and behavioral phenotypes are less severe when compared to phenotypes observed in mice carrying Mecptm4.1Brd and Mecptm5.1Brd
• onset of phenotypes is gradual as compared to mice carrying Mecptm4.1Brd and Mecptm5.1Brd
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• decrease in latency to fall in 3-day accelerated rotarod-learning paradigm by day 3 as compared to controls
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• increased time in open arms of elevated plus maze as compared to controls, but not as compared to Mecptm3.1Brd (WT-GFP) control
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• increase in latency to fall in hanging wire test as compared to controls
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• median survival is 42 weeks
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:227401 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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