All Phenotypes Ranbp9<tm1Wyan> MGI Mouse

abnormal sperm flagellum morphology ( J:222184 )

• epididymal sperm shows a variety of morphological abnormalities in the flagellum including coiled or headless flagellum

coiled sperm flagellum ( J:222184 )

abnormal sperm head morphology ( J:222184 )

• epididymal sperm shows a variety of morphological abnormalities in the sperm head like crooked, round, or bent heads

decreased male germ cell number ( J:222184 )

• seminiferous epithelium is thinner in 3 month old testes and contains numerous vacuoles, indicative of germ cell depletion

• presence of numerous degenerating/degenerated spermatids, or even spermatocytes in the epididymis; this enhanced depletion of spermatocytes and spermatids and the production of deformed spermatozoa are seen only in mice older than 2 months and no differences are seen during the first wave of spermatogenesis

• proportional increase of meiotic cells (i.e.spermatocytes) and decrease in haploid cells (spermatids) despite lowered total cell number in both populations, indicating active depletion of spermatocytes and spermatids

oligozoospermia ( J:222184 )

• sperm counts are lower in 12 week old males

increased male germ cell apoptosis ( J:222184 )

• about 2-fold increase in apoptotic cells, mainly spermatocytes and early round spermatids, in the testes

• seminiferous tubules at around stage VI exhibit round spermatids with an increase in unrepaired DNA double-strand breaks

decreased sperm progressive motility ( J:222184 )

asthenozoospermia ( J:222184 )

• total motility and progressive motility of sperm are reduced in 12 week old males

abnormal seminiferous tubule epithelium morphology ( J:222184 )

• seminiferous epithelium is thinner in 3 month old testes and contains numerous vacuoles

small testis ( J:222184 )

• 12 week old males exhibit reduced testis size

decreased testis weight ( J:222184 )

• 12 week old males exhibit reduced testis weight

small caput epididymis ( J:222184 )

small epididymis ( J:222184 )

• caput and cauda epididymides are smaller

reduced male fertility ( J:222184 )

• males exhibit reduced fertility in 5-month long fertility tests, with some males completely infertile and others close to normal fertility