All Phenotypes Hic2<Gt(E225A08)1.1Wrst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hic2^{Gt(E225A08)1.1Wrst}
gene trap E225A08, 1.1, German Gene Trap Consortium
MGI:5703657

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst}	involves: 129P2/OlaHsd	MGI:5707465
cn2	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Tg(Mef2c-cre)2Blk/?	involves: 129P2/OlaHsd	MGI:5707469
cn3	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd	MGI:5707467
cn4	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:5707466
cn5	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Mesp1^tm2(cre)Ysa/Mesp1⁺	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	MGI:5707468

Allelic Composition	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2^{Gt(E225A08)1.1Wrst} mutation (0 available); any Hic2 mutation (258 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:225226 )

N	• no heart defects

Allelic Composition	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Tg(Mef2c-cre)2Blk/?
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2^{Gt(E225A08)1.1Wrst} mutation (0 available); any Hic2 mutation (258 available)
Tg(Mef2c-cre)2Blk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:225226 )

N	• no embryonic lethality

cardiovascular system

cardiovascular system phenotype ( J:225226 )

N	• no heart defects or external phenotype

Allelic Composition	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2^{Gt(E225A08)1.1Wrst} mutation (0 available); any Hic2 mutation (258 available)
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:225226 )

N	• no embryonic lethality to E15.5

embryo

embryonic growth retardation ( J:225226 )

• 19% with mild developmental delay and hemorrhage

cardiovascular system

thin myocardium ( J:225226 )

• in 40% of mice

overriding aortic valve ( J:225226 )

• in 80% of mice

ventricular septal defect ( J:225226 )

• 80% with ventricular septal defects

hemorrhage ( J:225226 )

• in mice showing developmental delay

growth/size/body

embryonic growth retardation ( J:225226 )

• 19% with mild developmental delay and hemorrhage

muscle

thin myocardium ( J:225226 )

• in 40% of mice

Allelic Composition	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Hic2^{Gt(E225A08)1.1Wrst} mutation (0 available); any Hic2 mutation (258 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:225226 )

N	• no embryonic or perinatal lethality

Allelic Composition	Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2^{Gt(E225A08)1.1Wrst} mutation (0 available); any Hic2 mutation (258 available)
Mesp1^tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:225226 )

• 78% lethality by 21 days of age

prenatal lethality, incomplete penetrance ( J:225226 )

• 26% mortality by E13.5

embryo

embryo phenotype ( J:225226 )

N	• embryos grossly normal to E10.5

cardiovascular system

thin myocardium ( J:225226 )

• in 38% of E13.5 embryos

overriding aortic valve ( J:225226 )

• in 69% of E13.5 embryos

atrial septal defect ( J:225226 )

• short atrial septa

ventricular septal defect ( J:225226 )

• 69% with ventricular septal defects in E13.5 embryos

hemorrhage ( J:225226 )

• in 40% of E13.5 embryos

homeostasis/metabolism

edema ( J:225226 )

• in 20% of E13.5 embryos

muscle

thin myocardium ( J:225226 )

• in 38% of E13.5 embryos

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