Phenotypes associated with this allele

• Allele Symbol: Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn
• Allele Name: transgene insertion 1, Karoly Mirnics
• Allele ID: MGI:5703789
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn/?	C57BL/6-Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn	MGI:5704169

Genotype
MGI:5704169

tg1

• Allelic Composition: Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn/?
• Genetic Background: C57BL/6-Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to amphetamine ( J:210380 )

♂ • attenuated response following administration of amphetamine

♂ • decreased ambulation in comparison to controls following administration of amphetamine

enhanced cued conditioning behavior ( J:210380 )

♂ • increased fear retention in cue-based memory assessment

♂ • freezing behavior is not extinguished across multiple trials

slow extinction of fear memory ( J:210380 )

♂

increased startle reflex ( J:210380 )

♂ • mice treated with a CNR1 agonist exhibit increased startle response when means are compared across 4 tone intensities

♂ • however, startle response to pre-pulse inhibition is not altered between controls and mutants

♂ • elevated peak startle as compared to controls

abnormal social investigation ( J:210380 )

♂ • increased preference for social novelty (second stimulus mouse) versus familiar mouse in three chamber social task

homeostasis/metabolism

increased serotonin level ( J:210380 )

♂ • observed in mice treated with a CNR1 agonist or amphetamine