Phenotypes associated with this allele

• Allele Symbol: Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn
• Allele Name: transgene insertion 3, Karoly Mirnics
• Allele ID: MGI:5703933
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn/?	C57BL/6-Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn	MGI:5704175

Genotype
MGI:5704175

tg1

• Allelic Composition: Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn/?
• Genetic Background: C57BL/6-Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

slow extinction of fear memory ( J:227902 )

♂ • freezing behavior is reduced by 20% as compared to 50% in wild-type controls

abnormal response to novel object ( J:227902 )

♂ • mice spend more time investigating novel object as compared to controls

♂ • increased physical interaction with novel object as compared to controls

increased startle reflex ( J:227902 )

♂ • increased startle responses at low sound intensities

decreased vertical activity ( J:227902 )

♂ • decreased rearing in response to ketamine (an NMDA antagonist) at 5 mg/kg dose as compared to wild-type

increased vertical activity ( J:227902 )

♂ • increased rearing in response to ketamine (an NMDA antagonist) at 2.5 mg/kg dose as compared to wild-type

abnormal social investigation ( J:227902 )

♂ • increased preference for social novelty (new mouse) versus familiar mouse

nervous system

abnormal GABA-mediated receptor currents ( J:227902 )

♂ • reduction in spontaneous inhibitory postsynaptic currents (sIPSCs) frequency measured in pyramidal neurons from Layer V of the prelimbic region of the prefrontal cortex

♂ • however, amplitude and kinetics are not changed

decreased prepulse inhibition ( J:227902 )

♂ • impaired prepulse inhibition as assessed by lack of startle response with increased sound intensities