Phenotypes associated with this allele

• Allele Symbol: Gdf2^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5703975
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf2^tm1Lex/Gdf2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5708081
ht2	Gdf2^tm1Lex/Gdf2^+	involves: 129S5/SvEvBrd * C57BL/6	MGI:5708082

Genotype
MGI:5708081

hm1

• Allelic Composition: Gdf2^tm1Lex/Gdf2^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Neutralization of BMP10 causes defective vascular development in Gdf2^tm1Lex/Gdf2⁺ and Gdf2^tm1Lex/Gdf2^tm1Lex mice

cardiovascular system

cardiovascular system phenotype ( J:222016 )

N • surprisingly, untreated homozygotes are viable and fertile and do not display any embryonic or early postnatal defects in vascular development

N • overall morphology and density of the retinal vasculature is normal at P7

N • similarly, neonatal tracheal blood vasculature and tracheal lymphatic vessels appear normal

abnormal blood vessel morphology ( J:222016 )

• after treatment with anti-BMP10, neonatal homozygotes show a disorganized tracheal blood vasculature, unlike similarly treated wild-type controls

abnormal retina vasculature morphology ( J:222016 )

• after treatment with anti-BMP10 monoclonal antibody from P2 through P7, neonatal homozygotes display abnormal retinal vasculature, unlike similarly treated wild-type controls

• after treatment with anti-BMP10, retinal vascular density is markedly increased

abnormal retina blood vessel morphology ( J:222016 )

• after treatment with anti-BMP10, affected retinal blood vessels show reduced coverage of alphaSMA-positive mural cells

abnormal retina blood vessel pattern ( J:222016 )

• after treatment with anti-BMP10, expansion of the vascular plexus in the nerve fiber layer from the optic nerve head (ONH) is markedly delayed

immune system

abnormal lymphatic vessel morphology ( J:222016 )

• after treatment with anti-BMP10, P7 tracheal lymphatic vessels appear highly irregular

lymphangiectasis ( J:222016 )

• after treatment with anti-BMP10, P7 tracheal lymphatic vessels appear dilated

vision/eye

abnormal retina vasculature morphology ( J:222016 )

• after treatment with anti-BMP10 monoclonal antibody from P2 through P7, neonatal homozygotes display abnormal retinal vasculature, unlike similarly treated wild-type controls

• after treatment with anti-BMP10, retinal vascular density is markedly increased

abnormal retina blood vessel morphology ( J:222016 )

• after treatment with anti-BMP10, affected retinal blood vessels show reduced coverage of alphaSMA-positive mural cells

abnormal retina blood vessel pattern ( J:222016 )

• after treatment with anti-BMP10, expansion of the vascular plexus in the nerve fiber layer from the optic nerve head (ONH) is markedly delayed

Genotype
MGI:5708082

ht2

• Allelic Composition: Gdf2^tm1Lex/Gdf2⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Neutralization of BMP10 causes defective vascular development in Gdf2^tm1Lex/Gdf2⁺ and Gdf2^tm1Lex/Gdf2^tm1Lex mice

cardiovascular system

abnormal retina vasculature morphology ( J:222016 )

• after treatment with anti-BMP10 monoclonal antibody from P2 through P7, heterozygotes show less severe defects in retinal vasculature relative to similarly treated homozygotes

• after treatment with anti-BMP10, retinal vascular density is increased to a lesser extent than in similarly treated homozygotes

• however, untreated heterozygotes exhibit normal retinal vasculature

vision/eye

abnormal retina vasculature morphology ( J:222016 )

• after treatment with anti-BMP10 monoclonal antibody from P2 through P7, heterozygotes show less severe defects in retinal vasculature relative to similarly treated homozygotes

• after treatment with anti-BMP10, retinal vascular density is increased to a lesser extent than in similarly treated homozygotes

• however, untreated heterozygotes exhibit normal retinal vasculature