Phenotypes associated with this allele
Allelic
Composition |
Ube3atm1Yelg/Ube3a+
|
|
Genetic
Background |
involves: 129P2/OlaHsd * 129S2/SvPasCrl |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ube3atm1Yelg mutation
(0 available);
any
Ube3a mutation
(68 available)
|
|
|
cellular
|
|
• this allele is maternally inherited and silenced in males by imprinting
|
behavior/neurological
|
|
• mice with a maternally inherited allele exhibit alterations in marble burying, showing a higher number of unburied marbles than controls
|
|
|
• mice inheriting the mutant allele from the mother exhibit alterations in the forced swim test, showing increased floating time compared to controls
|
|
|
• mice inheriting the mutant allele from the mother exhibit alterations in rotarod performance, showing shorter latencies to fall off the rod
|
|
|
• mice with a maternally inherited allele exhibit alterations in open field explorations, showing shorter path lengths than controls
|
|
|
• mice with a maternally inherited allele exhibit alterations in nest building; the percent of used nesting is lower in mutants than in controls indicating decreased nest building
|
|
|
• mice with a maternally inherited allele exhibit alterations in audiogenic seizure threshold, showing a large increase in mice with seizures
• treatment of adults with either valproate or clonazepam for 5 days prevents audiogenic seizures
|
nervous system
|
|
• mice with a maternally inherited allele exhibit alterations in audiogenic seizure threshold, showing a large increase in mice with seizures
• treatment of adults with either valproate or clonazepam for 5 days prevents audiogenic seizures
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre)13Miya mutation
(1 available)
Ube3atm1Yelg mutation
(0 available);
any
Ube3a mutation
(68 available)
|
|
|
behavior/neurological
|
N |
• mice with a maternally inherited allele exhibit a full rescue of neurological and behavioral abnormalities (rotarod, marble burying, open field explorations, nest building, audiogenic seizure threshold, and forced swim test)
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation
(10 available)
Ube3atm1Yelg mutation
(0 available);
any
Ube3a mutation
(68 available)
|
|
|
behavior/neurological
|
|
• mice with a maternally inherited allele treated with tamoxifen at 3, 6, or 14 weeks of age show alterations in marble burying, indicating no rescue of this phenotype when gene expression is re-established at those times
• tamoxifen treatment of mice with a maternally inherited allele immediately after birth via administration to lactating dams does not rescue the deficits in marble burying
|
|
|
• mice treated with tamoxifen at 3, 6, or 14 weeks of age show alterations in the forced swim test, indicating no rescue of this phenotype
• tamoxifen treatment of mice with a maternally inherited allele immediately after birth via administration to lactating dams does not rescue the deficits in the forced swim test
|
|
|
• mice with a maternally inherited allele treated with tamoxifen at 14 weeks (adults) do not show any rescue of motor coordination deficit at 28 weeks of age
• however, mice with a maternally inherited allele treated with tamoxifen at 6 weeks (adolescents) show partial rescue of motor coordination deficit at 22 weeks of age and mice treated with tamoxifen at 3 weeks (juveniles) show full rescue of motor coordination deficit at 16 weeks of age
• tamoxifen treatment of mice with a maternally inherited allele immediately after birth via administration to lactating dams rescues fully the motor coordination deficit
|
|
|
• mice with a maternally inherited allele treated with tamoxifen at 3, 6, or 14 weeks of age show alterations in the open field explorations, indicating no rescue of this phenotype
• however, tamoxifen treatment of mice with a maternally inherited allele immediately after birth via administration to lactating dams results in improved performance in the open field
|
|
|
• mice with a maternally inherited allele treated with tamoxifen at 3, 6, or 14 weeks of age show alterations in nest building, indicating no rescue of this phenotype
• tamoxifen treatment of mice with a maternally inherited allele immediately after birth via administration to lactating dams does not rescue the deficits in nest building
|
|
|
• mice with a maternally inherited allele treated with tamoxifen at 3 weeks of age show increased audiogenic seizure threshold, indicating no rescue of this phenotype
|
nervous system
|
|
• mice with a maternally inherited allele treated with tamoxifen at 3 weeks of age show increased audiogenic seizure threshold, indicating no rescue of this phenotype
|
|
|
• mice with a maternally inherited allele not treated with tamoxifen exhibit abnormal Schaffer collateral-CA1 long term potentiation indicating a hippocampal plasticity deficit
• mice with a maternally inherited allele show full recovery of hippocampal LTP when treated with tamoxifen at 3 and 14 weeks of age
|
Analysis Tools