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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elp3tm1.1Tac
targeted mutation 1.1, Taconic
MGI:5704311
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Apctm1Tno/Apctm1Tno
Elp3tm1.1Tac/Elp3tm1.1Tac
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac MGI:5898005
cn2
 		Elp3tm1.1Tac/Elp3tm1.1Tac
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac MGI:5898004
cn3
 		ApcMin/Apc+
Elp3tm1.1Tac/Elp3tm1.1Tac
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL MGI:5898003
cn4
 		Elp3tm1.1Tac/Elp3tm1.1Tac
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL MGI:5898002


Genotype
MGI:5898005
cn1
Allelic
Composition		 Apctm1Tno/Apctm1Tno
Elp3tm1.1Tac/Elp3tm1.1Tac
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (6 available); any Apc mutation (158 available)
Elp3tm1.1Tac mutation (0 available); any Elp3 mutation (40 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal epithelium morphology ( J:227334 )
• the amount of Dclk1+/Sox9+ cells in the Lgr5+ population is decreased in ex vivo organoids
abnormal small intestinal crypt cell physiology ( J:227334 )
• intestinal crypts fail to efficiently generate spheroid structures ex vivo

neoplasm
decreased tumor growth/size ( J:227334 )
• tamoxifen treated mice exhibit decreased numbers of hyperplastic foci/polyps in the intestine indicating impaired tumor initiation




Genotype
MGI:5898004
cn2
Allelic
Composition		 Elp3tm1.1Tac/Elp3tm1.1Tac
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elp3tm1.1Tac mutation (0 available); any Elp3 mutation (40 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:227334 )
N
• tamoxifen treated mice show normal numbers of Lgr5+ cells in intestinal crypts




Genotype
MGI:5898003
cn3
Allelic
Composition		 ApcMin/Apc+
Elp3tm1.1Tac/Elp3tm1.1Tac
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Elp3tm1.1Tac mutation (0 available); any Elp3 mutation (40 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal gastrointestinal brush cell morphology ( J:227334 )
• the number of Tuft cells in the intestinal epithelium are slightly decreased

digestive/alimentary system
digestive/alimentary phenotype ( J:227334 )
N
• crypt cell proliferation and cell apoptosis at the top of the villi remain unchanged compared to single ApcMin mutants
abnormal gastrointestinal brush cell morphology ( J:227334 )
• the number of Tuft cells in the intestinal epithelium are slightly decreased
abnormal intestinal epithelium morphology ( J:227334 )
• the number of Dclk1+ cells in both tumors and adjacent regions are decreased in the intestine
• the number of Tuft cells are slightly decreased
• the number of Dckl1+/acetylated alpha-tubulin-negative cells are highly decreased
decreased intestinal adenoma incidence ( J:227334 )
• mice exhibit decreased tumor number in proximal, middle, and distal intestines compared to single ApcMin mutants and expanded life span

neoplasm
decreased intestinal adenoma incidence ( J:227334 )
• mice exhibit decreased tumor number in proximal, middle, and distal intestines compared to single ApcMin mutants and expanded life span
increased tumor latency ( J:227334 )
• mice exhibit delayed tumor appearance in intestinal epithelia compared to single ApcMin mutants

hematopoietic system
hematopoietic system phenotype ( J:227334 )
N
• mice do not exhibit decreased hematocrit levels as seen in single ApcMin mutants

immune system
immune system phenotype ( J:227334 )
N
• mice do not exhibit splenomegaly




Genotype
MGI:5898002
cn4
Allelic
Composition		 Elp3tm1.1Tac/Elp3tm1.1Tac
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elp3tm1.1Tac mutation (0 available); any Elp3 mutation (40 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal gastrointestinal brush cell morphology ( J:227334 )
• the number of Tuft cells is decreased in intestinal epithelium

digestive/alimentary system
abnormal gastrointestinal brush cell morphology ( J:227334 )
• the number of Tuft cells is decreased in intestinal epithelium
abnormal intestinal epithelium morphology ( J:227334 )
• the number of Dclk1+ cells is decreased in intestinal crypts, suggesting impaired Tuft cell differentiation
• the number of Tuft cells is decreased in intestinal epithelium
impaired intestine regeneration ( J:227334 )
• the number of regenerating crypts following irradiation is decreased compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory