Phenotypes associated with this allele

• Allele Symbol: Gabrb1^m1Qnma
• Allele Name: mutation 1, Quentin M Anstee
• Allele ID: MGI:5704358
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gabrb1^m1Qnma/Gabrb1^+	involves: BALB/cAnN * C3H/HeH	MGI:5704367

Genotype
MGI:5704367

ht1

• Allelic Composition: Gabrb1^m1Qnma/Gabrb1⁺
• Genetic Background: involves: BALB/cAnN * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal corpus luteum morphology ( J:223500 )

• underdeveloped

female infertility ( J:223500 )

homeostasis/metabolism

decreased follicle stimulating hormone level ( J:223500 )

• in the pituitary

decreased growth hormone level ( J:223500 )

• in the pituitary

decreased luteinizing hormone level ( J:223500 )

• in the pituitary

decreased prolactin level ( J:223500 )

• in the pituitary

decreased thyroid-stimulating hormone level ( J:223500 )

• in the pituitary

behavior/neurological

behavior/neurological phenotype ( J:223500 )

N • mice exhibit normal preference for sucrose, saccharine and quinine solutions and normal daily fluid intake

alcohol preference ( J:223500 )

enhanced behavioral response to alcohol ( J:223500 )

• increased ataxia and loss of righting reflex

• however, peak or time course of blood and brain alcohol levels are normal

abnormal operant conditioning behavior ( J:223500 )

• mice exhibit increased alcohol seeking behavior and slower decreased desire for alcohol as they consume in an operant self-administration system compared with wild-type mice

nervous system

abnormal single cell response ( J:223500 )

• nucleus accumbens medium spiny neurons exhibit increased tonic inhibition compared with wild-type cells

abnormal miniature inhibitory postsynaptic currents ( J:223500 )

• nucleus accumbens medium spiny neurons exhibit reduced miniature inhibitory postsynaptic currents (mIPSCs) frequency and prolonged decay time but increased mIPSC amplitude compared to in wild-type cells

increased miniature inhibitory postsynaptic current amplitude ( J:223500 )

• in nucleus accumbens medium spiny neurons

decreased miniature inhibitory postsynaptic current frequency ( J:223500 )

• in nucleus accumbens medium spiny neurons

growth/size/body

decreased body size ( J:223500 )

• more pronounced than in Gabrb1^m2Qnma heterozygotes

endocrine/exocrine glands

abnormal corpus luteum morphology ( J:223500 )

• underdeveloped