All Phenotypes Sle21<C57BL/6> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sle21^C57BL/6
C57BL/6
MGI:5704364

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fcgr2b^tm1Ttk/Fcgr2b^tm1.2Jsv Sle21^129P2/Ola/Sle21^C57BL/6	involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5427953
cx2	C1qa^tm1Mjw/C1qa^tm1Mjw Sle21^129P2/Ola/Sle21^C57BL/6	involves: 129P2/Ola * 129S/SvEv * C57BL/6	MGI:3701670

Allelic Composition	Fcgr2b^tm1Ttk/Fcgr2b^tm1.2Jsv Sle21^129P2/Ola/Sle21^C57BL/6
Genetic Background	involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2b^tm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Sle21^129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21^C57BL/6 mutation (0 available); any Sle21 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179175 )

• mice exhibit greater cumulative death compared with wild-type C57BL/6 mice

immune system

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased susceptibility to systemic lupus erythematosus ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-chromatin antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-double stranded DNA antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-histone antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-single stranded DNA antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

renal/urinary system

albuminuria ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

abnormal kidney morphology ( J:179175 )

• kidney pathology is increased compared to in wild-type C57BL/6 mice

homeostasis/metabolism

albuminuria ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

hematopoietic system

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

growth/size/body

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

Allelic Composition	C1qa^tm1Mjw/C1qa^tm1Mjw Sle21^129P2/Ola/Sle21^C57BL/6
Genetic Background	involves: 129P2/Ola * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qa^tm1Mjw mutation (1 available); any C1qa mutation (24 available)
Sle21^129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21^C57BL/6 mutation (0 available); any Sle21 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:118645 )

increased anti-nuclear antigen antibody level ( J:118645 )

increased anti-chromatin antibody level ( J:118645 )

increased anti-double stranded DNA antibody level ( J:118645 )

increased anti-single stranded DNA antibody level ( J:118645 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24