All Phenotypes Sle21<C57BL/6> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sle21^C57BL/6
C57BL/6
MGI:5704364

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fcgr2b^tm1Ttk/Fcgr2b^tm1.2Jsv Sle21^129P2/Ola/Sle21^C57BL/6	involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5427953
cx2	C1qa^tm1Mjw/C1qa^tm1Mjw Sle21^129P2/Ola/Sle21^C57BL/6	involves: 129P2/Ola * 129S/SvEv * C57BL/6	MGI:3701670

Allelic Composition	Fcgr2b^tm1Ttk/Fcgr2b^tm1.2Jsv Sle21^129P2/Ola/Sle21^C57BL/6
Genetic Background	involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2b^tm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Sle21^129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21^C57BL/6 mutation (0 available); any Sle21 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179175 )

• mice exhibit greater cumulative death compared with wild-type C57BL/6 mice

immune system

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased susceptibility to systemic lupus erythematosus ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-chromatin antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-double stranded DNA antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-histone antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased anti-single stranded DNA antibody level ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

renal/urinary system

albuminuria ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

abnormal kidney morphology ( J:179175 )

• kidney pathology is increased compared to in wild-type C57BL/6 mice

homeostasis/metabolism

albuminuria ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

hematopoietic system

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

growth/size/body

enlarged spleen ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

increased spleen weight ( J:179175 )

• not as severe as in Fcgr2b^tm1Ttk homozygotes

Allelic Composition	C1qa^tm1Mjw/C1qa^tm1Mjw Sle21^129P2/Ola/Sle21^C57BL/6
Genetic Background	involves: 129P2/Ola * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qa^tm1Mjw mutation (1 available); any C1qa mutation (24 available)
Sle21^129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21^C57BL/6 mutation (0 available); any Sle21 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:118645 )

increased anti-nuclear antigen antibody level ( J:118645 )

increased anti-chromatin antibody level ( J:118645 )

increased anti-double stranded DNA antibody level ( J:118645 )

increased anti-single stranded DNA antibody level ( J:118645 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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