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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gdap1tm1Ics
targeted mutation 1, Mouse Clinical Institute
MGI:5704441
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gdap1tm1Ics/Gdap1tm1Ics
Mnx1tm4(cre)Tmj/Mnx1+ 		involves: 129S1/Sv MGI:5789300
cn2
 		Gdap1tm1Ics/Gdap1tm1Ics
Tg(Mpz-cre)26Mes/0 		involves: FVB/NTac MGI:5789297


Genotype
MGI:5789300
cn1
Allelic
Composition		 Gdap1tm1Ics/Gdap1tm1Ics
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdap1tm1Ics mutation (0 available); any Gdap1 mutation (23 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:221297 )
N
• mice exhibit normal nerve conduction velocities and compound muscle action potentials




Genotype
MGI:5789297
cn2
Allelic
Composition		 Gdap1tm1Ics/Gdap1tm1Ics
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdap1tm1Ics mutation (0 available); any Gdap1 mutation (23 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
dysmyelination ( J:221297 )
• hypomyelination of the plantar nerve in 19 month old mice with no axonal loss

cellular
cellular phenotype ( J:221297 )
N
• axonal area covered by mitochondria in axons of plantar nerves is similar to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory