Phenotypes associated with this allele

• Allele Symbol: Gdap1^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:5704443
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdap1^tm1.1Ics/Gdap1^tm1.1Ics	Not Specified	MGI:5789302

Genotype
MGI:5789302

hm1

• Allelic Composition: Gdap1^tm1.1Ics/Gdap1^tm1.1Ics
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

dysmyelination ( J:221297 )

• hypomyelination of the plantar nerve in 19 month old mice, with no axonal loss

• remyelination of nerve fibers after sciatic nerve crush is less effective than in wild-type mice resulting in hypomyelination of large caliber axons

• however, hypomyelination is not seen in the ventral funiculus of the spinal cord

abnormal action potential ( J:221297 )

• after stimulation at the sciatic notch (proximal stimulation), compound muscle action potential amplitudes are reduced in 19 month old mutants

decreased nerve conduction velocity ( J:221297 )

• 19, but not 14, month old mice exhibit a 25% reduction in nerve conduction velocities

abnormal axonal transport ( J:221297 )

• more mitochondria in dorsal root ganglion explant cultures from E13.5 embryos pause during anterograde transport events while pausing lasts longer for mitochondria transported in retrograde direction

cellular

increased mitochondrial DNA content ( J:221297 )

• the mitochondrial to genomic DNA-ratio is increased in the sciatic nerve, indicating increased mitochondrial DNA content

increased mitochondrial size ( J:221297 )

• axonal area covered by mitochondria in axons of plantar nerves is increased due to increased size of mitochondria but not increased numbers

oxidative stress ( J:221297 )

• mild oxidative stress in peripheral nerves