Phenotypes associated with this allele

• Allele Symbol: Trit1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5704516
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trit1^tm1.1(KOMP)Vlcg/Trit1^tm1.1(KOMP)Vlcg	B6N(Cg)-Trit1^tm1.1(KOMP)Vlcg/J	MGI:6263776
hm2	Trit1^tm1.1(KOMP)Vlcg/Trit1^tm1.1(KOMP)Vlcg	C57BL/6N-Trit1^tm1.1(KOMP)Vlcg/JMmucd	MGI:6376184
ht3	Trit1^tm1.1(KOMP)Vlcg/Trit1^+	B6N(Cg)-Trit1^tm1.1(KOMP)Vlcg/J	MGI:6263775

Genotype
MGI:6263776

hm1

• Allelic Composition: Trit1^{tm1.1(KOMP)Vlcg}/Trit1^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Trit1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13142A-H7

Data Sources

IMPC Data for Trit1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6376184

hm2

• Allelic Composition: Trit1^{tm1.1(KOMP)Vlcg}/Trit1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Trit1^{tm1.1(KOMP)Vlcg}/JMmucd
• Cell Lines: 13142A-H7

Trit1^{tm1.1(KOMP)Vlcg}/Trit1^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with fewer than expected number of embryos at E7.5 and no embryos at E9.5. Though an egg cyclinder is formed, no morphological node or other hallmarks typical of E7.5 are present.

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:279207 )

• although normal blastocysts are present in expected Mendelian ratios at E3.5, very few homozygous embryos can be recovered at E7.5 (7% vs expected 25%, n=43)

• in vitro, blastocysts hatch from the zona pellucida and form fairly normal outgrowth colonies after 3 days in culture

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• no homozygous embryos are identified at E9.5

embryo

failure to gastrulate ( J:290315 , J:279207 )

• although an egg cylinder has formed, no morphological node or other hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no morphological node is present at E7.5

Genotype
MGI:6263775

ht3

• Allelic Composition: Trit1^{tm1.1(KOMP)Vlcg}/Trit1⁺
• Genetic Background: B6N(Cg)-Trit1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13142A-H7

Data Sources

IMPC Data for Trit1

behavior/neurological

decreased grip strength ( J:211773 )

♀

IMPC - JAX