Phenotypes associated with this allele

• Allele Symbol: Tg(Prnp-ATXN7*92Q*D266N)1239Als
• Allele Name: transgene insertion 1239, Albert R La Spada
• Allele ID: MGI:5705125
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Prnp-ATXN7*92Q*D266N)1239Als/0	B6J.Cg-Tg(Prnp-ATXN7*92Q*D266N)1239Als	MGI:5705130

Genotype
MGI:5705130

tg1

• Allelic Composition: Tg(Prnp-ATXN7*92Q*D266N)1239Als/0
• Genetic Background: B6J.Cg-Tg(Prnp-ATXN7*92Q*D266N)1239Als

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:222402 )

• average lifespan is 57.3 weeks on average, shorter than in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:222402 )

N • mice exhibit normal performance on an accelerating rotarod at 14 weeks of age and do not exhibit clasping, kyphosis or impairments on the ledge test

nervous system

nervous system phenotype ( J:222402 )

N • Purkinje cell dendritic arborization appears normal at 24 weeks of age

vision/eye

vision/eye phenotype ( J:222402 )

N • retinas appear normal at 24 weeks of age and mice show normal ERG responses at 22 weeks of age