All Phenotypes Alk<tm1.1Ics> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Alk^tm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5705324

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Alk^tm1.1Ics/? Tg(Th-MYCN)41Waw/0	involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J	MGI:5789375
ot2	Alk^tm1.1Ics/?	involves: 129S2/SvPas * C57BL/6	MGI:5789371

Allelic Composition	Alk^tm1.1Ics/? Tg(Th-MYCN)41Waw/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alk^tm1.1Ics mutation (0 available); any Alk mutation (64 available)
Tg(Th-MYCN)41Waw mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased neuroblastoma incidence ( J:228124 , J:261033 )

• tumors are classified as neuroblastoma, stroma-poor, poorly differentiated or differentiating (J:228124)

• tumor onset occurs later than in mice carrying the Alk^tm2.1Ics allele (J:228124)

• abdominal tumors are median, perivascular and locally invasive without evidence of macroscopic tumor spread to other organs (J:228124)

• tumors at 2 or 3 locations (abdominal/thoracic/cervical) are seen in 70% of mice (J:228124)

• mice treated with vandetanib, a kinase inhibitor, or crizotinib, show a reduction in abdominal tumor weight (J:228124)

mortality/aging

premature death ( J:261033 )

• mice begin to die around 100 days of age, with 70% survival at 200-300 days of age

nervous system

increased neuroblastoma incidence ( J:228124 , J:261033 )

• tumors are classified as neuroblastoma, stroma-poor, poorly differentiated or differentiating (J:228124)

• tumor onset occurs later than in mice carrying the Alk^tm2.1Ics allele (J:228124)

• abdominal tumors are median, perivascular and locally invasive without evidence of macroscopic tumor spread to other organs (J:228124)

• tumors at 2 or 3 locations (abdominal/thoracic/cervical) are seen in 70% of mice (J:228124)

• mice treated with vandetanib, a kinase inhibitor, or crizotinib, show a reduction in abdominal tumor weight (J:228124)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:228124 , J:261033

Allelic Composition	Alk^tm1.1Ics/?
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alk^tm1.1Ics mutation (0 available); any Alk mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal stellate ganglion morphology ( J:228124 )

• enlargement of the stellate ganglia

enlarged superior cervical ganglion ( J:228124 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24