Phenotypes associated with this allele

• Allele Symbol: Dmrtb1^tm1.1Zark
• Allele Name: targeted mutation 1.1, David Zarkower
• Allele ID: MGI:5705340
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmrtb1^tm1.1Zark/Dmrtb1^tm1.1Zark	involves: 129S1/Sv	MGI:5707840
hm2	Dmrtb1^tm1.1Zark/Dmrtb1^tm1.1Zark	involves: 129S1/Sv * C57BL/6	MGI:5707838

Genotype
MGI:5707840

hm1

• Allelic Composition: Dmrtb1^tm1.1Zark/Dmrtb1^tm1.1Zark
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:217504 )

♂N • Background Sensitivity: minimal loss of spermatogonia

abnormal male meiosis ( J:217504 )

♂ • more cells entering meiosis

arrest of male meiosis ( J:217504 )

♂ • meiosis arrested in prophase

♂ • spermatocytes do not progress past pachynema

abnormal synaptonemal complex ( J:217504 )

♂ • formation of complex begins but often fails to be completed in males

cellular

abnormal male meiosis ( J:217504 )

♂ • more cells entering meiosis

arrest of male meiosis ( J:217504 )

♂ • meiosis arrested in prophase

♂ • spermatocytes do not progress past pachynema

abnormal synaptonemal complex ( J:217504 )

♂ • formation of complex begins but often fails to be completed in males

Genotype
MGI:5707838

hm2

• Allelic Composition: Dmrtb1^tm1.1Zark/Dmrtb1^tm1.1Zark
• Genetic Background: involves: 129S1/Sv * C57BL/6

reproductive system

reproductive system phenotype ( J:217504 )

N • females are fertile and normal with no apparent ovarian defects

abnormal male germ cell apoptosis ( J:217504 )

♂ • Background Sensitivity: apoptotic cells in tubules of the testes containing late stage spermatogonia

abnormal testis morphology ( J:217504 )

♂

abnormal seminiferous tubule morphology ( J:217504 )

♂ • no mature spermatozoa in seminiferous tubules at 8 weeks of age

small testis ( J:217504 )

♂ • small testes at 10 days of age with no differentiating germ cells

♂ • sertioli cells are present

arrest of spermatogenesis ( J:217504 )

♂ • undifferentiated spermatogonia appear to be normal

♂ • XY bodies absent in differentiating spermatogonia

♂ • severe deficiency of germ cells from late spermatogonial stage onward

abnormal epididymis morphology ( J:217504 )

♂ • no mature spermatozoa in epididymis at 8 weeks of age

cellular

abnormal male germ cell apoptosis ( J:217504 )

♂ • Background Sensitivity: apoptotic cells in tubules of the testes containing late stage spermatogonia

endocrine/exocrine glands

abnormal testis morphology ( J:217504 )

♂

abnormal seminiferous tubule morphology ( J:217504 )

♂ • no mature spermatozoa in seminiferous tubules at 8 weeks of age

small testis ( J:217504 )

♂ • small testes at 10 days of age with no differentiating germ cells

♂ • sertioli cells are present