Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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homeostasis/metabolism
renal/urinary system
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• kidney weight and morphology appears normal at 4 months of age under normal physiologic conditions and circulating markers of kidney function, BUN, and plasma creatinine concentrations are normal
• mice exhibit a similar level of renal failure induced by ischemia/reperfusion and similar level of renal damage induced by FA injection as controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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homeostasis/metabolism
renal/urinary system
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• mice exhibit decreased renal damage induced by ischemia/reperfusion, showing reduced tubular damage with fewer obstructing casts, reduced levels of plasma creatinine and BUN levels compared to controls and increased survival rate after 48 hours after ischemia/reperfusion
• mice exhibit increased kidney tubular cell proliferation and decreased apoptosis 48 hours after ischemia/reperfusion
• however, mice treated with doxycycline to turn off expression exhibit similar renal damage to ischemia/reperfusion as controls
• under normal physiologic conditions, kidney weight and morphology appears normal at 4 months of age and circulating markers of kidney function, BUN, and plasma creatinine concentrations are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ggt1-tTA)#Agoc mutation
(0 available)
Tg(tetO-MYC)36aBop mutation
(1 available)
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renal/urinary system
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• removal of doxycycline (dox) results in increased kidney size
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• removal of dox results in the development of rapidly progressing of renal cell carcinoma
• marker analysis indicates that tumor subtype is of the collecting-duct carcinoma which exhibits a distinct lipid signature
• treatment with dox reverses tumor and results in regression of the renal cell carcinoma
• initiation of renal cell carcinoma is associated with the activation of glutaminolysis
• treatment with dox to suppress MYC protein expression results in regression of the renal cell carcinoma due to inhibition of proliferation accompanied by the persistence of apoptosis
• treatment with an inhibitor of kidney type glutaminase BPTES slows progression of renal cell carcinoma tumors, reduces neoplastic cells, and decreases kidney cell proliferation
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neoplasm
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• removal of dox results in the development of rapidly progressing of renal cell carcinoma
• marker analysis indicates that tumor subtype is of the collecting-duct carcinoma which exhibits a distinct lipid signature
• treatment with dox reverses tumor and results in regression of the renal cell carcinoma
• initiation of renal cell carcinoma is associated with the activation of glutaminolysis
• treatment with dox to suppress MYC protein expression results in regression of the renal cell carcinoma due to inhibition of proliferation accompanied by the persistence of apoptosis
• treatment with an inhibitor of kidney type glutaminase BPTES slows progression of renal cell carcinoma tumors, reduces neoplastic cells, and decreases kidney cell proliferation
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growth/size/body
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• removal of doxycycline (dox) results in increased kidney size
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Analysis Tools