Analysis Tools
homeostasis/metabolism
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• mice exhibit decreased renal damage induced by ischemia/reperfusion, showing reduced tubular damage with fewer obstructing casts, reduced levels of plasma creatinine and BUN levels compared to controls and increased survival rate after 48 hours after ischemia/reperfusion
• mice exhibit increased kidney tubular cell proliferation and decreased apoptosis 48 hours after ischemia/reperfusion
• however, mice treated with doxycycline to turn off expression exhibit similar renal damage to ischemia/reperfusion as controls
• under normal physiologic conditions, kidney weight and morphology appears normal at 4 months of age and circulating markers of kidney function, BUN, and plasma creatinine concentrations are normal
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renal/urinary system
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• mice exhibit decreased renal damage induced by ischemia/reperfusion, showing reduced tubular damage with fewer obstructing casts, reduced levels of plasma creatinine and BUN levels compared to controls and increased survival rate after 48 hours after ischemia/reperfusion
• mice exhibit increased kidney tubular cell proliferation and decreased apoptosis 48 hours after ischemia/reperfusion
• however, mice treated with doxycycline to turn off expression exhibit similar renal damage to ischemia/reperfusion as controls
• under normal physiologic conditions, kidney weight and morphology appears normal at 4 months of age and circulating markers of kidney function, BUN, and plasma creatinine concentrations are normal
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