All Phenotypes Ngly1<tm1.1Tasuz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ngly1^tm1.1Tasuz
targeted mutation 1.1, Tadashi Suzuki
MGI:5705596

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ngly1^tm1.1Tasuz/Ngly1^tm1.1Tasuz	B6.Cg-Ngly1^tm1.1Tasuz	MGI:5896599
cx2	Engase^tm1Tasuz/Engase^tm1Tasuz Ngly1^tm1.1Tasuz/Ngly1^tm1.1Tasuz	B6.Cg-Engase^tm1Tasuz Ngly1^tm1.1Tasuz	MGI:5896601
cx3	Fbxo2^tm1Yuyos/Fbxo2^tm1Yuyos Fbxo6^tm1Yuyos/Fbxo6^tm1Yuyos Ngly1^tm1.1Tasuz/Ngly1^tm1.1Tasuz	B6.Cg-Fbxo6^tm1Yuyos Fbxo2^tm1Yuyos Ngly1^tm1.1Tasuz	MGI:6758510
cx4	Fbxo2^tm1Yuyos/Fbxo2⁺ Fbxo6^tm1Yuyos/Fbxo6⁺ Ngly1^tm1.1Tasuz/Ngly1^tm1.1Tasuz	B6.Cg-Fbxo6^tm1Yuyos Fbxo2^tm1Yuyos Ngly1^tm1.1Tasuz	MGI:6758511

Allelic Composition	Ngly1^tm1.1Tasuz/Ngly1^tm1.1Tasuz
Genetic Background	B6.Cg-Ngly1^tm1.1Tasuz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngly1^tm1.1Tasuz mutation (2 available); any Ngly1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:307684 )

perinatal lethality, incomplete penetrance ( J:307684 )

cellular

abnormal cell physiology ( J:217663 )

• mouse embryonic fibroblasts exhibit dysregulation of the endoplasmic reticulum (ER)-associated degradation (ERAD) process

Allelic Composition	Engase^tm1Tasuz/Engase^tm1Tasuz Ngly1^tm1.1Tasuz/Ngly1^tm1.1Tasuz
Genetic Background	B6.Cg-Engase^tm1Tasuz Ngly1^tm1.1Tasuz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engase^tm1Tasuz mutation (1 available); any Engase mutation (26 available)
Ngly1^tm1.1Tasuz mutation (2 available); any Ngly1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:307684 )

cellular

cellular phenotype ( J:217663 )

N	• dysregulation of the endoplasmic reticulum (ER)-associated degradation (ERAD) process observed in Ngly1^tm1.1Tasuz homozygous mouse embryonic fibroblasts is restored

Allelic Composition	Fbxo2^tm1Yuyos/Fbxo2^tm1Yuyos Fbxo6^tm1Yuyos/Fbxo6^tm1Yuyos Ngly1^tm1.1Tasuz/Ngly1^tm1.1Tasuz
Genetic Background	B6.Cg-Fbxo6^tm1Yuyos Fbxo2^tm1Yuyos Ngly1^tm1.1Tasuz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo2^tm1Yuyos mutation (0 available); any Fbxo2 mutation (22 available)
Fbxo6^tm1Yuyos mutation (1 available); any Fbxo6 mutation (35 available)
Ngly1^tm1.1Tasuz mutation (2 available); any Ngly1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:307684 )

nervous system

nervous system phenotype ( J:307684 )

N	• mice exhibit no pathological abnormality in the brain

behavior/neurological

behavior/neurological phenotype ( J:307684 )

N	• mice exhibit normal motor function

Allelic Composition	Fbxo2^tm1Yuyos/Fbxo2⁺ Fbxo6^tm1Yuyos/Fbxo6⁺ Ngly1^tm1.1Tasuz/Ngly1^tm1.1Tasuz
Genetic Background	B6.Cg-Fbxo6^tm1Yuyos Fbxo2^tm1Yuyos Ngly1^tm1.1Tasuz

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:307684 )

postnatal lethality, incomplete penetrance ( J:307684 )

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