Phenotypes associated with this allele

• Allele Symbol: Mlxip^tm1.2Lchan
• Allele Name: targeted mutation 1.2, Lawrence Chan
• Allele ID: MGI:5705614
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlxip^tm1.2Lchan/Mlxip^tm1.2Lchan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6259436

Genotype
MGI:6259436

hm1

• Allelic Composition: Mlxip^tm1.2Lchan/Mlxip^tm1.2Lchan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:217834 )

N • normal fasting glucose levels, glucose tolerance test responses, and plasma lipid profiles under basal chow-fed conditions

increased fatty acid oxidation ( J:217834 )

• indicated by lowered in serum palmitoylcarnitine and NEFAs levels in mice after non-intensive exercise compared to wild-type controls

increased circulating alanine level ( J:217834 )

• mild exercise significantly increased alanine levels

increased circulating lactate level ( J:217834 )

• plasma levels are increased in mice fasted for 4h compared to similarly treated wild-type mice

• however, levels are similar to controls in mice fasted for 24h

• plasma levels are increased in mice fasted for 24h and then refed with a high-sucrose diet for 18h compared to similarly treated controls

• short term non-intensive exercise more than doubles plasma lactate levels

decreased respiratory quotient ( J:217834 )

• under mild exercise conditions mice have a lower respiratory exchange ratio compared to controls

• however, in the resting state respiratory exchange ratios are similar to controls

enhanced exercise endurance ( J:217834 )

• perform better at sprint exercise with a terminal speed that is ~30% compared to controls

• performance in endurance exercise assays is similar to controls

growth/size/body

growth/size/body region phenotype ( J:217834 )

N • body weight and growth curves are similar to controls

muscle

abnormal muscle physiology ( J:217834 )

• decreased glucose oxidation rates in isolated skeletal muscle

• impaired pyruvate dehydrogenase activity in skeletal muscle

cellular

increased fatty acid oxidation ( J:217834 )

• indicated by lowered in serum palmitoylcarnitine and NEFAs levels in mice after non-intensive exercise compared to wild-type controls