Phenotypes associated with this allele

• Allele Symbol: Fhl1^tm1.1Mihi
• Allele Name: targeted mutation 1.1, Michio Hirano
• Allele ID: MGI:5705759
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Fhl1^tm1.1Mihi/Y	involves: 129S/SvEv * C57BL/6J * C57BL/6NJ	MGI:5706792

Genotype
MGI:5706792

ot1

• Allelic Composition: Fhl1^tm1.1Mihi/Y
• Genetic Background: involves: 129S/SvEv * C57BL/6J * C57BL/6NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:218097 )

♂ • 30% decrease in forelimb grip strength in 7-10 month old males

♂ • however, forelimb and hindlimb muscle strength is not impaired

impaired exercise endurance ( J:218097 )

♂ • decreased latency to fall (30%) as assessed by rotarod is observed in 7-10 month old males

♂ • latency to fall is increased to 35% in 8-10 month old animals

growth/size/body

decreased body weight ( J:218097 )

♂ • by 7-10 months of age body weight is reduced compared to wild-type mice

♂ • proportions of lean tissue, fat and fluid are similar to wild-type

homeostasis/metabolism

impaired exercise endurance ( J:218097 )

♂ • decreased latency to fall (30%) as assessed by rotarod is observed in 7-10 month old males

♂ • latency to fall is increased to 35% in 8-10 month old animals

muscle

decreased skeletal muscle fiber diameter ( J:218097 )

♂

centrally nucleated skeletal muscle fibers ( J:218097 )

♂

myopathy ( J:218097 )

♂ • mild myopathy characterized by focal reductions of muscle fiber diameter and increased internal nuclei is observed in 3 out of 7 10 month old males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
scapuloperoneal myopathy		DOID:0060253	OMIM:300695	J:218097