All Phenotypes Cdk4<tm2.2Bbd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdk4^tm2.2Bbd
targeted mutation 2.2, Mariano Barbacid
MGI:5705761

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk4^tm2.2Bbd/Cdk4^tm2.2Bbd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1 * SJL	MGI:5705782
cn2	Cdk4^tm2.2Bbd/Cdk4^tm2.2Bbd Kras^tm1Bbd/Kras^tm1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129S1/Sv * 129X1/SvJ	MGI:4844188
cn3	Cdk4^tm2.2Bbd/Cdk4^tm2.1Bbd Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129S1/Sv * 129X1/SvJ	MGI:4844192

Allelic Composition	Cdk4^tm2.2Bbd/Cdk4^tm2.2Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4^tm2.2Bbd mutation (0 available); any Cdk4 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:82809 )

Allelic Composition	Cdk4^tm2.2Bbd/Cdk4^tm2.2Bbd Kras^tm1Bbd/Kras^tm1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4^tm2.2Bbd mutation (0 available); any Cdk4 mutation (58 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (90 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:161780 )

• tamoxifen-treated mice exhibit reduced tumor burden and tumor grade compared with similarly treated Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

Allelic Composition	Cdk4^tm2.2Bbd/Cdk4^tm2.1Bbd Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4^tm2.1Bbd mutation (1 available); any Cdk4 mutation (58 available)
Cdk4^tm2.2Bbd mutation (0 available); any Cdk4 mutation (58 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (90 available)
Kras^tm2Bbd mutation (0 available); any Kras mutation (90 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:161780 )

• tamoxifen-treated mice infected with a flp-expressing adenovirus exhibit decreased proliferation and early senescence of tumor cells compared with tamoxifen and infected with GFP-expressing adenovirus

decreased tumor incidence ( J:161780 )

• tamoxifen-treated mice infected with a flp-expressing adenovirus exhibit reduced lesions compared to in mice treated with tamoxifen and infected with GFP-expressing adenovirus

increased tumor incidence ( J:161780 )

• in tamoxifen-treated mice as in similarly treated Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

cellular

decreased cell proliferation ( J:161780 )

• tamoxifen-treated mice infected with a flp-expressing adenovirus exhibit early senescence of tumor cells compared with tamoxifen and infected with GFP-expressing adenovirus

early cellular replicative senescence ( J:161780 )

• tamoxifen-treated mice infected with a flp-expressing adenovirus exhibit decreased proliferation of tumor cells compared with tamoxifen and infected with GFP-expressing adenovirus

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