mortality/aging
• no living homozygous embryos after E9.5
• some embryos still alive at E8.5
|
embryo
• development through formation of head folds, heart, and allantois but embryos never turn
|
• E8.5 embryos similar in size to wild type E7.5 embryos
• mutant embryos are developmentally retarded at E7.5
|
• no neural tube
|
• no organized somites
|
growth/size/body
• E8.5 embryos similar in size to wild type E7.5 embryos
• mutant embryos are developmentally retarded at E7.5
|
nervous system
• no neural tube
|