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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Glrx3tm1.1(KOMP)Vlcg
targeted mutation 1.1, Velocigene
MGI:5705872
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Glrx3tm1.1(KOMP)Vlcg/Glrx3tm1.1(KOMP)Vlcg B6N(Cg)-Glrx3tm1.1(KOMP)Vlcg/J MGI:6262530
ht2
Glrx3tm1.1(KOMP)Vlcg/Glrx3+ B6N(Cg)-Glrx3tm1.1(KOMP)Vlcg/J MGI:7316994


Genotype
MGI:6262530
hm1
Allelic
Composition
Glrx3tm1.1(KOMP)Vlcg/Glrx3tm1.1(KOMP)Vlcg
Genetic
Background
B6N(Cg)-Glrx3tm1.1(KOMP)Vlcg/J
Cell Lines 19731A-F11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glrx3tm1.1(KOMP)Vlcg mutation (1 available); any Glrx3 mutation (33 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype

Glrx3tm1.1(KOMP)Vlcg/Glrx3tm1.1(KOMP)Vlcg mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo
• no hallmarks typical of gastrulating embryos are observed at E7.5
• embryos arrest prior to gastrulation
• embryos are much smaller than controls at E7.5
• a rudimentary egg cylinder is observed at E7.5
• no head folds are present at E7.5
• no embryonic node is present at E7.5
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
• embryos are much smaller than controls at E7.5

mortality/aging
• homozygous embryos are recovered at E7.5 (16% versus expected 25%, n=37) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5




Genotype
MGI:7316994
ht2
Allelic
Composition
Glrx3tm1.1(KOMP)Vlcg/Glrx3+
Genetic
Background
B6N(Cg)-Glrx3tm1.1(KOMP)Vlcg/J
Cell Lines 19731A-F11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glrx3tm1.1(KOMP)Vlcg mutation (1 available); any Glrx3 mutation (33 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory