Phenotypes associated with this allele

• Allele Symbol: Glrx3^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5705872
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glrx3^tm1.1(KOMP)Vlcg/Glrx3^tm1.1(KOMP)Vlcg	B6N(Cg)-Glrx3^tm1.1(KOMP)Vlcg/J	MGI:6262530
ht2	Glrx3^tm1.1(KOMP)Vlcg/Glrx3^+	B6N(Cg)-Glrx3^tm1.1(KOMP)Vlcg/J	MGI:7316994

Genotype
MGI:6262530

hm1

• Allelic Composition: Glrx3^{tm1.1(KOMP)Vlcg}/Glrx3^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Glrx3^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 19731A-F11

Data Sources

IMPC Data for Glrx3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Glrx3^{tm1.1(KOMP)Vlcg}/Glrx3^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo

failure to gastrulate ( J:279207 )

• no hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

decreased egg cylinder size ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E7.5 (16% versus expected 25%, n=37) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:7316994

ht2

• Allelic Composition: Glrx3^{tm1.1(KOMP)Vlcg}/Glrx3⁺
• Genetic Background: B6N(Cg)-Glrx3^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 19731A-F11

Data Sources

IMPC Data for Glrx3

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - JAX