All Phenotypes E2f4<tm2.1Lees> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

E2f4^tm2.1Lees
targeted mutation 2.1, Jacqueline A Lees
MGI:5706731

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	E2f4^tm2.1Lees/E2f4^tm2.1Lees E2f5^tm1Dli/E2f5⁺ Tg(Vil1-cre)20Syr/0	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2	MGI:5706798
cn2	E2f4^tm2.1Lees/E2f4^tm2.1Lees Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6	MGI:5904345
cn3	E2f4^tm2.1Lees/E2f4^tm2.1Lees Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6	MGI:5904347
cn4	E2f4^tm2.1Lees/E2f4^tm2.1Lees Tg(Vil1-cre)20Syr/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:5706796
cx5	E2f4^tm2.1Lees/E2f4^tm2.1Lees E2f5^tm1Dli/E2f5^tm1Dli	involves: 129S1/Sv * 129S4/SvJae * C57BL/6	MGI:5706800
cx6	E2f4^tm2.1Lees/E2f4⁺ E2f5^tm1Dli/E2f5^tm1Dli	involves: 129S1/Sv * 129S4/SvJae * C57BL/6	MGI:5706801

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees E2f5^tm1Dli/E2f5⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
E2f5^tm1Dli mutation (1 available); any E2f5 mutation (13 available)
Tg(Vil1-cre)20Syr mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:228346 )

N	• male mice exhibit normal spermatogenesis

dilated rete testis ( J:228346 )

• often contains many spermatozoa

abnormal seminiferous tubule epithelium morphology ( J:228346 )

• atrophic

dilated seminiferous tubule ( J:228346 )

• with dilation at that the expense of the epithelium

abnormal efferent ductules of testis morphology ( J:228346 )

• spermatozoa accumulate in the efferent ducts unlike in wild-type mice

• efferent duct epithelium lacks multiciliated cells and exhibit decreased abundance of endocytic vesicle apparatus

abnormal epididymis morphology ( J:228346 )

• no spermatozoa are detected in the epididymis

male infertility ( J:228346 )

endocrine/exocrine glands

dilated rete testis ( J:228346 )

• often contains many spermatozoa

abnormal seminiferous tubule epithelium morphology ( J:228346 )

• atrophic

dilated seminiferous tubule ( J:228346 )

• with dilation at that the expense of the epithelium

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiratory motile cilium morphology ( J:241925 )

• mice treated with 4-hydroxytamoxifen show disruption of multiciliogenesis in lung epithelium

• 4-hydroxytamoxifen treated mice are unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

cellular

abnormal respiratory motile cilium morphology ( J:241925 )

• mice treated with 4-hydroxytamoxifen show disruption of multiciliogenesis in lung epithelium

• 4-hydroxytamoxifen treated mice are unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiratory motile cilium morphology ( J:241925 )

• mice are unable to form multiciliated cells and unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

cellular

abnormal respiratory motile cilium morphology ( J:241925 )

• mice are unable to form multiciliated cells and unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Tg(Vil1-cre)20Syr mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:228346 )

• mice are viable and fertile with normal intestinal morphology and efferent duct epithelium

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees E2f5^tm1Dli/E2f5^tm1Dli
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

dilated rete testis ( J:228346 )

• in all mice

abnormal efferent ductules of testis morphology ( J:228346 )

• at 3 weeks, efferent duct epithelium exhibit reduced multiciliated cells compared with control mice

endocrine/exocrine glands

dilated rete testis ( J:228346 )

• in all mice

Allelic Composition	E2f4^tm2.1Lees/E2f4⁺ E2f5^tm1Dli/E2f5^tm1Dli
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

dilated rete testis ( J:228346 )

• in all mice

abnormal efferent ductules of testis morphology ( J:228346 )

• at 3 weeks, efferent duct epithelium exhibit reduced multiciliated cells compared with control mice

endocrine/exocrine glands

dilated rete testis ( J:228346 )

• in all mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24