About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc80tm1Ppal
targeted mutation 1, Pierlorenzo Pallante
MGI:5706809
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc80tm1Ppal/Ccdc80tm1Ppal Not Specified MGI:5790811
ht2
 		Ccdc80tm1Ppal/Ccdc80+ Not Specified MGI:5790812


Genotype
MGI:5790811
hm1
Allelic
Composition		 Ccdc80tm1Ppal/Ccdc80tm1Ppal
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc80tm1Ppal mutation (0 available); any Ccdc80 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased thyroid adenoma incidence ( J:217742 )
• 6 of 20 (30%) of homozygotes developed thyroid adenomas
• thyroid adenomas and ovarian carcinomas were never present in the same mouse
increased ovarian carcinoma incidence ( J:217742 )
• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis
increased metastatic potential ( J:217742 )
• 1 of 4 ovarian carcinomas showed the presence of liver metastasis

cellular
decreased fibroblast apoptosis ( J:217742 )
• after 72 hrs of serum starvation, the % of apoptotic MEFs (sub-G1 cell population) was lower than that in wild-type MEFs
• after treatment with 500 nM doxorubicin for 16 hrs, the % of TUNEL-positive MEFs was significantly lower than that in wild-type MEFs
increased fibroblast proliferation ( J:217742 )
• mouse embryonic fibroblasts (MEFs) derived from E12.5 embryos showed a significantly higher proliferation rate than wild-type MEFs

endocrine/exocrine glands
increased thyroid adenoma incidence ( J:217742 )
• 6 of 20 (30%) of homozygotes developed thyroid adenomas
• thyroid adenomas and ovarian carcinomas were never present in the same mouse
increased ovarian carcinoma incidence ( J:217742 )
• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis

reproductive system
increased ovarian carcinoma incidence ( J:217742 )
• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis




Genotype
MGI:5790812
ht2
Allelic
Composition		 Ccdc80tm1Ppal/Ccdc80+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc80tm1Ppal mutation (0 available); any Ccdc80 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast proliferation ( J:217742 )
• MEFs derived from E12.5 embryos showed an intermediate increase in their proliferation rate compared with wild-type and homozygous mutant MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory